hydroxytamoxifen

Nanomedicine, an emerging new field created by the fusion of nanotechnology and medicine, is one of the most promising pathways… Expand

The steroid hormone oestrogen can signal through several receptors and pathways. Although the transcriptional responses mediated… Expand

The growth of both normal and transformed epithelial cells of the female reproductive system is stimulated by estrogens, mainly… Expand

Evidence is presented that the estrogen antagonist 4-hydroxytamoxifen (HT) can occupy not only the core binding pocket within the… Expand

A series of ferrocene derivatives based upon the structure of the antiestrogenic drug tamoxifen or of its active metabolite… Expand

We used mouse hepatoma (Hepa1c1c7) cells to study the role of the serine/threonine kinase Akt in the induction ofGLUT1 gene… Expand

Nuclear receptors (NRs) bound to response elements mediate the effects of cognate ligands on gene expression. Their ligand… Expand

We have generated mutant mouse estrogen receptors which differ in their sensitivity to estrogen and the antiestrogen 4… Expand

Extracts containing wild-type or mutant human estrogen receptor (ER) have been used to study the binding of ER to its responsive… Expand

Although much attention has been paid to the removal of hormones from sera and to the development of serum-free media for studies… Expand