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hydroxymethylglutaryl-CoA synthase activity

Known as: acetoacetyl coenzyme A transacetase activity, (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity, HMG-CoA synthase activity 
Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). [EC:2.3.3.10, RHEA:10191]
National Institutes of Health

Papers overview

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2011
2011
E-mail: insukim@ulsan.ac.krReceived July 19, 2011, Accepted August 2, 2011Key Words : Fluvastatin, Asymmetric, Catalytic… Expand
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Highly Cited
2007
Highly Cited
2007
Thiolases are CoA-dependent enzymes which catalyze the formation of a carbon-carbon bond in a Claisen condensation step and its… Expand
Review
2002
Review
2002
  • D. Baker
  • Journal of cardiac failure
  • 2002
  • Corpus ID: 19553805
BACKGROUND The number of people in the United States with heart failure (HF) is expected to rise dramatically as the population… Expand
1998
1998
Cytosolic 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) synthase catalyzes the formation of HMG‐CoA, the substrate for the rate… Expand
Highly Cited
1997
Highly Cited
1997
OBJECTIVES We sought to document the common mechanisms of the antiatherogenic effects of the cholesterol-lowering hydroxy… Expand
1975
1975
1. Two mitochondrial forms of acetoacetyl-CoA thiolases designated as enzyme A and enzyme B were crystallized from ox liver. They… Expand
1973
1973
  • C. Parish
  • Cellular immunology
  • 1973
  • Corpus ID: 43632511
Abstract Acetoacetylation converts flagellin from an antigen which preferentially induces humoral antibodies to an antigen which… Expand
Highly Cited
1968
Highly Cited
1968
Abstract 1. 1. The crystallization of thiolase specific for long-chain β-keto-CoA derivatives (acyl-CoA:acetyl-CoA C… Expand
1963
1963
A number of laboratories (l-4) have investigated the biosynthesis of mevalonic acid from acetate or acetyl coenzyme ,4 by yeast… Expand
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1959
1959
Abstract In the reaction of succinate-O18 with acetoacetyl coenzyme A to form succinyl coenzyme A and acetoacetate, as catalyzed… Expand