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hydroxymethylglutaryl-CoA synthase activity

Known as: acetoacetyl coenzyme A transacetase activity, (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity, HMG-CoA synthase activity 
Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). [EC:2.3.3.10, RHEA:10191]
National Institutes of Health

Papers overview

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2017
2017
Neocarazostatin A (1) is a potent free radical scavenger possessing an intriguing tricyclic carbazole nucleus with a C4 alkyl… Expand
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2017
2017
Production of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in plant seed oils has been pursued to improve… Expand
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2007
2007
Thiolases are CoA-dependent enzymes which catalyze the formation of a carbon-carbon bond in a Claisen condensation step and its… Expand
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1998
1998
Cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase catalyzes the formation of HMG-CoA, the substrate for the rate… Expand
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Highly Cited
1997
Highly Cited
1997
OBJECTIVES We sought to document the common mechanisms of the antiatherogenic effects of the cholesterol-lowering hydroxy… Expand
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1990
1990
Two minor Colchicum alkaloids, N-acetoacetyl-deacetylcolchicine [1] and 2-demethylspeciosine [7], were synthesized. The diacetate… Expand
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1975
1975
1. Two mitochondrial forms of acetoacetyl-CoA thiolases designated as enzyme A and enzyme B were crystallized from ox liver. They… Expand
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1973
1973
Abstract Acetoacetylation converts flagellin from an antigen which preferentially induces humoral antibodies to an antigen which… Expand
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1968
1968
Abstract 1. 1. The crystallization of thiolase specific for long-chain β-keto-CoA derivatives (acyl-CoA:acetyl-CoA C… Expand
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1963
1963
A number of laboratories (l-4) have investigated the biosynthesis of mevalonic acid from acetate or acetyl coenzyme ,4 by yeast… Expand
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