hydroxymethylglutaryl-CoA synthase activity

Known as: acetoacetyl coenzyme A transacetase activity, (s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity, HMG-CoA synthase activity 
Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+). [EC:2.3.3.10, RHEA:10191]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2013
01219752013

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1998
1998
There are at least two isoenzymes of 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase (EC 4.1.3.5) located in the mitochondrial… (More)
Is this relevant?
1994
1994
In newborn-pig hepatocytes, the rate of oleate oxidation is extremely low, despite a very low malonyl-CoA concentration. By… (More)
Is this relevant?
1993
1993
Insects do not synthesize cholesterol; the 3-hydroxy-3-methylglutaryl-coenzyme-A (HMG-CoA) produced by HMG-CoA synthase is… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1990
1990
It has recently been reported that a precursor of p21ras (pro-p21ras) becomes modified by a metabolite of mevalonic acid prior to… (More)
Is this relevant?
1990
1990
We report the isolation and characterization of a 1994-base-pair cDNA that encompasses the entire transcription unit of the… (More)
Is this relevant?
1990
1990
Rat hepatic mitochondrial function, including oxidative phosphorylation, fatty acid oxidative capacity, kinetic parameters of… (More)
Is this relevant?
1989
1989
1. The activity of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase (EC 4.1.3.5) in extracts of rapidly frozen rat livers was… (More)
Is this relevant?
1987
1987
A beta-lactone isolated from Fusarium sp. has been shown to be a potent specific inhibitor of the enzyme 3-hydroxy-3… (More)
  • figure 2
  • figure 3
  • table 3
  • table 2
  • table 4
Is this relevant?
1986
1986
We here report the isolation and nucleotide sequencing of a full-length 3.3-kilobase cDNA for the cytoplasmic form of 3-hydroxy-3… (More)
Is this relevant?
1982
1982
Regulation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity and synthesis by 25-hydroxycholesterol is aberrant in a… (More)
Is this relevant?