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hyaluronan synthase activity

Known as: HAS activity, spHAS, alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity 
Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Hyaluronan (HA), the only non-sulfated glycosaminoglycan, is involved in morphogenesis, wound healing, inflammation, angiogenesis… Expand
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2006
2006
Size exclusion chromatography-multiangle laser light scattering (SEC-MALLS) analyses of Escherichia coli membranes expressing… Expand
2006
2006
  • P. Prehm
  • The Biochemical journal
  • 2006
  • Corpus ID: 6368998
The mechanism of hyaluronan biosynthesis in vertebrates had been proposed to occur at the reducing end of growing chains. This… Expand
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2006
2006
We identified two conserved polar amino acids within different membrane domains (MD) of Streptococcus equisimilis hyaluronan… Expand
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2005
2005
Hyaluronan (HA), a functionally essential glycosaminoglycan in vertebrate tissues and a putative virulence factor in certain… Expand
2004
2004
Hyaluronan synthase (HAS) utilizes UDP-GlcUA and UDP-GlcNAc in the presence of Mg(2+) to form the GAG hyaluronan (HA). The… Expand
Highly Cited
2001
Highly Cited
2001
Since we first reported (DeAngelis, P. L., Papaconstantinou, J., and Weigel, P. H. (1993) J. Biol. Chem. 268, 19181–19184) the… Expand
Highly Cited
1999
Highly Cited
1999
The two hyaluronan synthases (HASs) fromStreptococcus pyogenes (spHAS) and Streptococcus equisimilis (seHAS) were expressed in… Expand
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Highly Cited
1999
Highly Cited
1999
The two hyaluronan synthases (HASs) from Streptococcus pyogenes (spHAS) and Streptococcus equisimilis (seHAS) were expressed in… Expand
Highly Cited
1997
Highly Cited
1997
We previously reported the first cloning of a functional glycosaminoglycan synthase, the hyaluronan synthase (HAS) from Group A… Expand
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