hyaluronan synthase activity

Known as: HAS activity, spHAS, alternating UDP-alpha-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-[nascent hyaluronan] 4-N-acetyl-beta-D-glucosaminyltransferase and UDP-alpha-D-glucuronate:N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] 3-beta-D-glucuronosyltransferase activity 
Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
02419932017

Papers overview

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2015
2015
Hyaluronan (HA) is a component of the extracellular matrix that is involved in many physiological and pathological processes. As… (More)
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2009
2009
Hyaluronan (HA), the only non-sulfated glycosaminoglycan, is involved in morphogenesis, wound healing, inflammation, angiogenesis… (More)
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2009
2009
Cytokines such as tumour necrosis factor-alpha (TNFalpha), interferon-gamma (IFNgamma), and transforming growth factor-beta… (More)
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2008
2008
Engineering of hyaluronic acid (HA) biosynthetic pathway in recombinant Escherichia coli as production host is reported in this… (More)
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2004
2004
Hyaluronan synthase (HAS) utilizes UDP-GlcUA and UDP-GlcNAc in the presence of Mg(2+) to form the GAG hyaluronan (HA). The… (More)
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2001
2001
Since we first reported (DeAngelis, P. L., Papaconstantinou, J., and Weigel, P. H. (1993) J. Biol. Chem. 268, 19181-19184) the… (More)
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1999
1999
The two hyaluronan synthases (HASs) from Streptococcus pyogenes (spHAS) and Streptococcus equisimilis (seHAS) were expressed in… (More)
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1998
1998
In the present study we describe a method to prepare membranes with high hyaluronan synthase activity from human glioma cells by… (More)
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1997
1997
We previously reported the first cloning of a functional glycosaminoglycan synthase, the hyaluronan synthase (HAS) from Group A… (More)
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1996
1996
We developed a mammalian transient expression system to isolate cDNA clones that determine hyaluronan expression. HAS-, a mouse… (More)
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