hormone-sensitive lipase activity

Known as: HSL, diacylglycerol acylhydrolase activity 
Catalysis of the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Lipolysis is the catabolic pathway by which triglycerides are hydrolyzed into fatty acids. Adipose triglyceride lipase (ATGL) and… (More)
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Highly Cited
2007
Highly Cited
2007
AIM/HYPOTHESIS Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The… (More)
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Highly Cited
2006
Highly Cited
2006
The mobilization of free fatty acids from adipose triacylglycerol (TG) stores requires the activities of triacylglycerol lipases… (More)
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Highly Cited
2006
Highly Cited
2006
Hormone-sensitive lipase (HSL) is the predominant lipase effector of catecholamine-stimulated lipolysis in adipocytes. HSL… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE To directly ascertain the physiological roles in adipocytes of hormone-sensitive lipase (HSL; E.C. 3.1.1.3), a… (More)
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Highly Cited
2000
Highly Cited
2000
Because the enzymic regulation of muscle triglyceride breakdown is poorly understood we studied whether neutral lipase in… (More)
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Highly Cited
1999
Highly Cited
1999
The enzymic regulation of triacylglycerol breakdown in skeletal muscle is poorly understood. Western blotting of muscle fibres… (More)
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Highly Cited
1998
Highly Cited
1998
Hormone-sensitive lipase (HSL) is the rate-limiting enzyme in lipolysis. Stimulation of rat adipocytes with isoproterenol results… (More)
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Highly Cited
1994
Highly Cited
1994
Hormone-sensitive lipase (HSL) mediates the lipolysis of triacylglycerol from mammalian adipocytes, resulting in the release of… (More)
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1994
1994
To investigate the factors controlling maternal depot fat accumulation during early pregnancy and net decrease during late… (More)
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