homogentisate 1,2-dioxygenase activity

Known as: homogentisic oxygenase activity, homogentisicase activity, homogentisate oxidase activity 
Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). [EC:1.13.11.5, RHEA:15452]
National Institutes of Health

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Topic mentions per year

1962-2014
01219622014

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2015
2015
Melanin production is important to the pathogenicity and survival of some bacterial pathogens. In Bacillus anthracis, loss of… (More)
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2014
2014
BACKGROUND Alkaptonuria, a rare autosomal recessive metabolic disorder caused by deficiency in homogentisate 1,2-dioxygenase… (More)
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2012
2012
Alkaptonuria (AKU) is an ultra-rare disease developed from the lack of homogentisic acid oxidase activity, causing homogentisic… (More)
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2010
2010
OBJECTIVES Alkaptonuria (AKU) is a rare genetic disease associated with deficient homogentisate 1,2-dioxygenase activity in the… (More)
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2006
2006
Alkaptonuria is a rare, autosomal recessive metabolic disorder in which the homogentisic acid oxidase activity is absent. Its… (More)
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2002
2002
In alkaptonuria, homogentisate 1,2-dioxygenase deficiency causes tissue accumulation of homogentisic acid (HGA), followed by… (More)
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1999
1999
Sinorhizobium meliloti strain N4 carries a Tn5luxAB insertion in a gene which is induced by nitrogen and carbon deprivation as… (More)
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1997
1997
The presence of homogentisic acid (HGA) in urine is diagnostic for alkaptonuria, a classical example of a biochemical lesion… (More)
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1995
1995
We report here the first characterization of a gene encoding a homogentisate dioxygenase, the Aspergillus nidulans hmgA gene. The… (More)
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1994
1994
Alkaptonuria (AKU; McKusick no. 203500) is a rare autosomal recessive disorder caused by the lack of homogentisic acid oxidase… (More)
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