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homocamptothecin

Known as: hCPT 
 
National Institutes of Health

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2 relations

Broader (1)

Camptothecin
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
PEG-chitosan-coated iron oxide nanoparticles with high saturated magnetization as carriers of 10-hydroxycamptothecin: preparation, characterization and cytotoxicity studies.
A magnetic nano-sized carrier for 10-hydroxycamptothecin (HCPT) was prepared by using Fe(3)O(4) nanoparticles as cores and… Expand
Highly Cited
2010
Highly Cited
2010
Nanodiamonds as intracellular transporters of chemotherapeutic drug.
To explore the application of nanodiamonds (NDs) as anticancer drug delivery vehicles, firstly we examined the toxicity of NDs to… Expand
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Highly Cited
2010
Highly Cited
2010
Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG-nanoparticles.
The aim of the study was to prepare transferrin modified stealth nanoparticles (Tf-PEG-NP) encapsulating poly(ethylene) glycol… Expand
Highly Cited
2009
Highly Cited
2009
Covalently combining carbon nanotubes with anticancer agent: preparation and antitumor activity.
A multiwalled carbon nanotube (MWNT)-based drug delivery system was developed by covalently combining carbon nanotubes with the… Expand
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Highly Cited
2007
Highly Cited
2007
Preparation, characterization and biodistribution of the lactone form of 10-hydroxycamptothecin (HCPT)-loaded bovine serum albumin (BSA) nanoparticles.
10-Hydroxycamptothecin (HCPT) is insoluble in both water and physiological acceptable organic solvents and tends to change into… Expand
Highly Cited
2007
Highly Cited
2007
10-Hydroxycamptothecin loaded nanoparticles: preparation and antitumor activity in mice.
10-Hydroxycamptothecin (HCPT) loaded nanoparticles made from poly(caprolactone-co-lactide)-b-PEG-b-poly(caprolactone-co-lactide… Expand
Highly Cited
2000
Highly Cited
2000
Topoisomerase I-mediated antiproliferative activity of enantiomerically pure fluorinated homocamptothecins.
Homocamptothecin (hCPT) is an E-ring modified camptothecin (CPT) analogue bearing a methylene spacer between the alcohol and… Expand
Highly Cited
1999
Highly Cited
1999
Homocamptothecin, an E-ring modified camptothecin with enhanced lactone stability, retains topoisomerase I-targeted activity and antitumor properties.
Homocamptothecin (hCPT) is a semisynthetic analogue of camptothecin (CPT) with a seven-membered beta-hydroxylactone resulting… Expand
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Highly Cited
1998
Highly Cited
1998
Preclinical pharmacology of the natural product anticancer agent 10-hydroxycamptothecin, an inhibitor of topoisomerase I
Purpose: 10-Hydroxycamptothecin (HCPT) is an indole alkaloid isolated from a Chinese tree, Camptotheca acuminata, and has a wide… Expand
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Highly Cited
1998
Highly Cited
1998
Homocamptothecins: synthesis and antitumor activity of novel E-ring-modified camptothecin analogues.
Homocamptothecin (hCPT), a camptothecin (CPT) analogue with a seven membered beta-hydroxylactone which combines enhanced plasma… Expand
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