homoaconitate hydratase activity

Known as: Lys4, 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity, homoaconitase activity 
Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O. [EC:4.2.1.36, RHEA:15488]
National Institutes of Health

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Highly Cited
2007
Highly Cited
2007
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact on gene expression, we measured… (More)
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Highly Cited
2007
Highly Cited
2007
Epigenetic modifications are crucial for proper lineage specification and embryo development. To explore the chromatin… (More)
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Highly Cited
2006
Highly Cited
2006
Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with transcription activation. A common feature of several H3K4… (More)
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Highly Cited
2006
Highly Cited
2006
Mammalian circadian rhythms are based on transcriptional and post-translational feedback loops. Essentially, the activity of the… (More)
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Highly Cited
2006
Highly Cited
2006
MLL complexes are homologs of yeast COMPASS capable of methylating histone H3 Lys4 (H3K4). ASH2L, RbBP5 and WDR5 are conserved… (More)
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Highly Cited
2006
Highly Cited
2006
The WD40-repeat protein WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes. WDR5 has been… (More)
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Highly Cited
2005
Highly Cited
2005
The organization of eukaryotic genomes into distinct structural and functional domains is important for the regulation and… (More)
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Highly Cited
2003
Highly Cited
2003
Besides serving to package nuclear DNA, histones carry information in the form of a diverse array of post-translational… (More)
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Highly Cited
2001
Highly Cited
2001
Eukaryotic genomes are organized into discrete structural and functional chromatin domains. Here, we show that distinct site… (More)
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Highly Cited
2001
Highly Cited
2001
Histone methylation is known to be associated with both transcriptionally active and repressive chromatin states. Recent studies… (More)
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