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histone deacetylase 6

Known as: EC 3.5.1.98, HD6, HDAC6 
Histone deacetylase 6 (1215 aa, ~131 kDa) is encoded by the human HDAC6 gene. This protein plays a role in the unfolded protein response, cell… 
National Institutes of Health

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Cell Cycle ProgressionChromatin Remodeling FactorDeacetylationDevelopmental process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice
Cilia are present in most vertebrate tissues with a wide variety of functions, and abnormalities of cilia are linked to numerous… 
2016
2016
[Synthesis and anti-tumor activity of novel histone deacetylase inhibitors based on dihydropyridin-2-one scaffold].
To discover novel dihydropyridin-2-one derivatives with higher HDAC inhibitory activity and subtype selectivity, twenty-seven… 
2016
2016
Abstract 3996: KA2237 and KA2507: Novel, oral cancer immunotherapeutics targeting PI3K-p110β/p110δ and HDAC6 with single-agent and combination activity
Two de novo-designed classes of orally-active immunotherapeutics - selectively targeting the PI3K-p110β/p110δ and HDAC6 enzymes… 
2015
2015
Abstract 5380: Selective HDAC inhibition by ricolinostat (ACY-1215) or ACY-241 synergizes with IMiD® immunomodulatory drugs in Multiple Myeloma (MM) and Mantle Cell Lymphoma (MCL) cells
Histone deacetylase (HDAC) enzymes are attractive therapeutic targets in oncology, but non-selective HDAC inhibitors have led to… 
2015
2015
Abstract 1338: Novel implications of histone deacetylase 6 selective inhibition in melanoma T-cell immunotherapy
Adoptive T-cell therapy is an effective treatment for metastatic melanoma, achieving objective clinical responses in half of… 
2010
2010
PANORAMA 2: A phase II study of panobinostat (LBH589) in combination with bortezomib (BTZ) and dexamethasone (DEX) in patients with relapsed and BTZ-refractory multiple myeloma (MM).
TPS308 Background: BTZ, a backbone of novel therapy for patients (pts) with MM, is an effective agent but pts will relapse and… 
2010
2010
Introgression of three heading date genes, hd1, Hd6, and ehd1, to Oryza sativa L. japonica cv. Koshihikari by marker-assisted selection.
2007
2007
Boyault C, Sadoul K, Pabion M, Khochbin S.. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 26: 5468-5476
2002
2002
FK 228 ( Depsipeptide ) as a Natural Prodrug That Inhibits Class I Histone Deacetylases 1
FK228 is a histone deacetylase (HDAC) inhibitor, the molecular mechanism of inhibition of which has been unknown. Here we show… 
1987
1987
Phenotypic modulation of chronic lymphocytic, prolymphocytic, and lymphoplasmacytic leukemia cells by TPA: induction of TRAP isoenzyme 5 and HD6 (CD22) antigen and enhancement of IgM messenger RNA.
B-cell neoplasias such as CLL can be viewed as models of monoclonal populations restricted within discrete ranges of B-cell…