histone deacetylase 6

Known as: EC 3.5.1.98, HD6, HDAC6 
Histone deacetylase 6 (1215 aa, ~131 kDa) is encoded by the human HDAC6 gene. This protein plays a role in the unfolded protein response, cell… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Posttranslational modifications play important roles in regulating protein structure and function. Histone deacetylase 6 (HDAC6… (More)
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Highly Cited
2008
Highly Cited
2008
Histone deacetylase 6 (HDAC6), a unique cytoplasmic deacetylase, likely plays a role in neurodegeneration by coordinating cell… (More)
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Highly Cited
2007
Highly Cited
2007
A defect in microtubule (MT)-based transport contributes to the neuronal toxicity observed in Huntington's disease (HD). Histone… (More)
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Highly Cited
2007
Highly Cited
2007
Histone deacetylase 6 (HDAC6) is a cytoplasmic deacetylase that uniquely catalyzes alpha-tubulin deacetylation and promotes cell… (More)
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Highly Cited
2005
Highly Cited
2005
The hydroxamic acid (HAA) analogue pan-histone deacetylase (HDAC) inhibitors (HDIs) LAQ824 and LBH589 have been shown to induce… (More)
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Highly Cited
2003
Highly Cited
2003
Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four… (More)
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Highly Cited
2003
Highly Cited
2003
The efficient clearance of cytotoxic misfolded protein aggregates is critical for cell survival. Misfolded protein aggregates are… (More)
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Highly Cited
2003
Highly Cited
2003
The silent information regulator 2 protein (Sir2p) of Saccharomyces cerevisiae is an NAD-dependent histone deacetylase that plays… (More)
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Highly Cited
2002
Highly Cited
2002
Reversible acetylation of α-tubulin has been implicated in regulating microtubule stability and function. The distribution of… (More)
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Highly Cited
2002
Highly Cited
2002
Runx2 (Cbfa1, AML-3) is multifunctional transcription factor that is essential for osteoblast development. Runx2 binds specific… (More)
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