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histone deacetylase 2

Known as: Transcriptional Regulator Homolog RPD3, HD2, HDAC2 
A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 1; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7… Expand
National Institutes of Health

Related topics

Related topics

22 relations
Cell CycleChromatin Remodeling FactorDeacetylationEnzyme Gene
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Hdac2 protein, rat

Papers overview

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Review
2018
Review
2018
Impact of social relationships on Alzheimer’s memory impairment: mechanistic studies
Alzheimer’s disease (AD) is characterized by progressive memory and neuronal loss culminating in cognitive impairment that not… Expand
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Highly Cited
2011
Highly Cited
2011
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.
Transcription factor-based cellular reprogramming has opened the way to converting somatic cells to a pluripotent state, but has… Expand
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Highly Cited
2009
Highly Cited
2009
Antidepressant Actions of Histone Deacetylase Inhibitors
Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the… Expand
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Highly Cited
2009
Highly Cited
2009
HDAC2 negatively regulates memory formation and synaptic plasticity
Chromatin modifications, especially histone-tail acetylation, have been implicated in memory formation. Increased histone-tail… Expand
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Highly Cited
2007
Highly Cited
2007
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.
Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression through the removal of acetyl groups from… Expand
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Highly Cited
2006
Highly Cited
2006
Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
Glucocorticoids are the most effective antiinflammatory agents for the treatment of chronic inflammatory diseases even though… Expand
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Highly Cited
2005
Highly Cited
2005
Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1
Histone deacetylases (HDACs) 1 and 2 share a high degree of homology and coexist within the same protein complexes. Despite their… Expand
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Highly Cited
2004
Highly Cited
2004
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.
Oxidative stress is a characteristic of chronic inflammatory diseases. The reactive oxygen intermediate hydrogen peroxide (H(2)O… Expand
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Highly Cited
1999
Highly Cited
1999
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome… Expand
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Highly Cited
1997
Highly Cited
1997
Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression
Transcriptional repression by Mad-Max heterodimers requires interaction of Mad with the corepressors mSin3A/B. Sin3p, the S… Expand
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