histone deacetylase 2

Known as: Transcriptional Regulator Homolog RPD3, HD2, HDAC2 
A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 1; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7… (More)
National Institutes of Health

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22 relations
Cell CycleChromatin Remodeling FactorDeacetylationEnzyme Gene
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Hdac2 protein, rat

Papers overview

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Highly Cited
2008
Highly Cited
2008
S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons
Brain-derived neurotrophic factor (BDNF) and other neurotrophins have a vital role in the development of the rat and mouse… (More)
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Highly Cited
2007
Highly Cited
2007
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.
Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression through the removal of acetyl groups from… (More)
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Highly Cited
2006
Highly Cited
2006
Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
Glucocorticoids are the most effective antiinflammatory agents for the treatment of chronic inflammatory diseases even though… (More)
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Highly Cited
2005
Highly Cited
2005
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterized by chronic airway inflammation that is greater in… (More)
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Highly Cited
2005
Highly Cited
2005
Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1
Histone deacetylases (HDACs) 1 and 2 share a high degree of homology and coexist within the same protein complexes. Despite their… (More)
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Highly Cited
2004
Highly Cited
2004
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex.
The transcription factor Snail has been described as a direct repressor of E-cadherin expression during development and… (More)
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Highly Cited
2004
Highly Cited
2004
Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.
Oxidative stress is a characteristic of chronic inflammatory diseases. The reactive oxygen intermediate hydrogen peroxide (H(2)O… (More)
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Highly Cited
2002
Highly Cited
2002
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression.
Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in… (More)
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Highly Cited
1999
Highly Cited
1999
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome… (More)
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Highly Cited
1997
Highly Cited
1997
Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression
Transcriptional repression by Mad-Max heterodimers requires interaction of Mad with the corepressors mSin3A/B. Sin3p, the S… (More)
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