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histone H3-K27 demethylation

Known as: H3K27 demethylation 
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone. [GOC:sp, PMID:20023638]
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2017
02420132017

Papers overview

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2018
2018
Targeted inhibition of histone H3K27 demethylation is effective in high-risk neuroblastoma
High-risk neuroblastoma is often distinguished by amplification of MYCN and loss of differentiation potential. We performed high… (More)
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2017
2017
Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts
The H3K27 demethylases are involved in a variety of biological processes, including cell differentiation, proliferation, and cell… (More)
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Review
2017
Review
2017
Glutamine metabolism regulates Th 2 cell differentiation via the α-ketoglutalate-dependent demethylation of histone H 3 K 27
The acquisition of T cell functions seems to be closely linked to the reprogramming of the metabolic pathway. However, the impact… (More)
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Review
2017
Review
2017
Glutamine metabolism regulates Th2 cell differentiation via the α-ketoglutarate-dependent demethylation of histone H3K27
The acquisition of T cell functions seems to be closely linked to the reprogramming of the metabolic pathway. However, the impact… (More)
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2015
2015
The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation.
Interleukin (IL) 17-producing T helper (Th17) cells play critical roles in the clearance of extracellular bacteria and fungi as… (More)
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2015
2015
H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat in Ex Vivo Cultures of Resting CD4+ T Cells.
UNLABELLED Histone methyltransferase inhibitors (HMTis) and histone deacetylase inhibitors (HDACis) are reported to… (More)
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2015
2015
An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes
PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic modifications in the invertebrates… (More)
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2015
2015
The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation.
Brown adipocytes function to dissipate energy as heat through adaptive thermogenesis. Understanding the molecular mechanisms… (More)
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2013
2013
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.
Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII… (More)
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2013
2013
MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation
The MMSET (Multiple Myeloma SET domain) protein is overexpressed in multiple myeloma patients harboring the translocation t(4;14… (More)
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