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hexafluoroleucine

National Institutes of Health

Papers overview

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Review
2014
Review
2014
  • E. Marsh
  • Accounts of Chemical Research
  • 2014
  • Corpus ID: 8301724
Fluorine is all but absent from biology; however, it has proved to be a remarkably useful element with which to modulate the… 
2014
2014
(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2–5 steps… 
2011
2011
The self-assembly of amyloid peptides is influenced by hydrophobicity, charge, secondary structure propensity, and sterics… 
2009
2009
Like leucine? A leucine analogue containing a ketone has been incorporated into proteins in E. coli. Only E. coli strains… 
Highly Cited
2008
Highly Cited
2008
Protegrins are potent members of the beta-hairpin-forming class of antimicrobial peptides. Key to their antimicrobial activity is… 
Highly Cited
2006
Highly Cited
2006
There has recently been much interest in exploiting the unusual properties associated with fluorocarbons to modulate the… 
Highly Cited
2004
Highly Cited
2004
Several studies have demonstrated that proteins incorporating fluorinated analogues of hydrophobic amino acids such as leucine… 
2002
2002
[reaction: see text] 5,5,5,5',5',5'-Hexafluoroleucine (6), a fluorous analogue of leucine, is of considerable interest as a… 
Highly Cited
2001
Highly Cited
2001
Incorporation of nonnatural amino acid residues allows engineering of proteins with novel chemical functionality and unusual… 
2001
2001
[reaction in text] A novel, short, and efficient synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine (6) in greater than 99% ee…