hexafluoroleucine

Fluorine is all but absent from biology; however, it has proved to be a remarkably useful element with which to modulate the… Expand

(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2–5 steps… Expand

Like leucine? A leucine analogue containing a ketone has been incorporated into proteins in E. coli. Only E. coli strains… Expand

Protegrins are potent members of the beta-hairpin-forming class of antimicrobial peptides. Key to their antimicrobial activity is… Expand

There has recently been much interest in exploiting the unusual properties associated with fluorocarbons to modulate the… Expand

Several studies have demonstrated that proteins incorporating fluorinated analogues of hydrophobic amino acids such as leucine… Expand

[reaction: see text] 5,5,5,5',5',5'-Hexafluoroleucine (6), a fluorous analogue of leucine, is of considerable interest as a… Expand

Incorporation of nonnatural amino acid residues allows engineering of proteins with novel chemical functionality and unusual… Expand

[reaction in text] A novel, short, and efficient synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine (6) in greater than 99% ee… Expand