hexafluoroleucine
National Institutes of Health
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Fluorine is all but absent from biology; however, it has proved to be a remarkably useful element with which to modulate the…
(2S,4R)- and (2S,4S)-perfluoro-tert-butyl 4-hydroxyproline were synthesized (as Fmoc-, Boc-, and free amino acids) in 2–5 steps…
The self-assembly of amyloid peptides is influenced by hydrophobicity, charge, secondary structure propensity, and sterics…
Like leucine? A leucine analogue containing a ketone has been incorporated into proteins in E. coli. Only E. coli strains…
Protegrins are potent members of the beta-hairpin-forming class of antimicrobial peptides. Key to their antimicrobial activity is…
There has recently been much interest in exploiting the unusual properties associated with fluorocarbons to modulate the…
Several studies have demonstrated that proteins incorporating fluorinated analogues of hydrophobic amino acids such as leucine…
[reaction: see text] 5,5,5,5',5',5'-Hexafluoroleucine (6), a fluorous analogue of leucine, is of considerable interest as a…
Incorporation of nonnatural amino acid residues allows engineering
of proteins with novel chemical functionality and unusual…
[reaction in text] A novel, short, and efficient synthesis of (S)-5,5,5,5',5',5'-hexafluoroleucine (6) in greater than 99% ee…