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hepatocyte growth factor-regulated tyrosine kinase substrate
Known as:
HGS
HGS is a downstream signaling molecule. It undergoes tyrosine phosphorylation in response to IL2, CSF2, or HGF.
National Institutes of Health
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Related topics
Related topics
7 relations
Broader (2)
Endosomal Sorting Complexes Required for Transport
Phosphoproteins
HGS gene
Inhibition of Cell Proliferation
Signal Transduction
Signaling Pathway Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells
U. Testa
,
E. Petrucci
,
L. Pasquini
,
G. Castelli
,
E. Pelosi
Medicines
2018
Corpus ID: 4518056
Four main histological subtypes of ovarian cancer exist: serous (the most frequent), endometrioid, mucinous and clear cell; in…
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Highly Cited
2017
Highly Cited
2017
Skeletal muscle depletion during chemotherapy has a large impact on physical function in elderly Japanese patients with advanced non–small-cell lung cancer
T. Naito
,
Taro Okayama
,
+20 authors
Toshiaki Takahashi
BMC Cancer
2017
Corpus ID: 21655146
Elderly patient with advanced cancer is one of the most vulnerable populations. Skeletal muscle depletion during chemotherapy may…
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Highly Cited
2014
Highly Cited
2014
Bioimpedance phase angle predicts muscle function, quality of life and clinical outcome in maintenance hemodialysis patients
I. Beberashvili
,
A. Azar
,
+5 authors
Z. Averbukh
European Journal of Clinical Nutrition
2014
Corpus ID: 3064560
Background/Objectives:The association of bioimpedance phase angle (PA), as a measure of nutritional status, with muscle function…
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Highly Cited
2013
Highly Cited
2013
IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor
E. Scotti
,
Martino Calamai
,
+11 authors
P. Tontonoz
Molecular and Cellular Biology
2013
Corpus ID: 13453383
ABSTRACT The low-density lipoprotein receptor (LDLR) is a critical determinant of plasma cholesterol levels that internalizes…
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Review
2013
Review
2013
Wrapping up the bad news – HIV assembly and release
B. Meng
,
A. Lever
Retrovirology
2013
Corpus ID: 12739682
The late Nobel Laureate Sir Peter Medawar once memorably described viruses as ‘bad news wrapped in protein’. Virus assembly in…
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Highly Cited
2008
Highly Cited
2008
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells.
T. Würdinger
,
B. Tannous
,
+6 authors
Anna M. Krichevsky
Cancer Cell
2008
Corpus ID: 10291647
Highly Cited
2006
Highly Cited
2006
Combined treatment of colorectal tumours with agonistic TRAIL receptor antibodies HGS-ETR1 and HGS-ETR2 and radiotherapy: enhanced effects in vitro and dose-dependent growth delay in vivo
P. Marini
,
S. Denzinger
,
+7 authors
Claus Belka
Oncogene
2006
Corpus ID: 172175
We and others have demonstrated already that TRAIL (TNF-related apoptosis-inducing ligand) is a very promising candidate for…
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Highly Cited
2006
Highly Cited
2006
Monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) induces apoptosis in primary renal cell carcinoma cells in vitro and inhibits tumor growth in vivo…
Y. Zeng
,
X. Wu
,
+4 authors
Yoshiyuki Kakehi
International Journal of Oncology
2006
Corpus ID: 16562024
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) triggers apoptosis in a variety of tumor cells through two of its…
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Highly Cited
2002
Highly Cited
2002
A comparative analysis of nutritional parameters as predictors of outcome in male and female ESRD patients.
P. Stenvinkel
,
P. Bárány
,
S. Chung
,
B. Lindholm
,
O. Heimbürger
Nephrology, Dialysis and Transplantation
2002
Corpus ID: 13921591
BACKGROUND Many patients with end-stage renal disease (ESRD) are malnourished and cross-sectional studies show that markers of…
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Highly Cited
2002
Highly Cited
2002
Ligand‐Independent Degradation of Epidermal Growth Factor Receptor Involves Receptor Ubiquitylation and Hgs, an Adaptor Whose Ubiquitin‐Interacting Motif Targets Ubiquitylation by Nedd4
M. Katz
,
K. Shtiegman
,
+8 authors
Y. Yarden
Traffic : the International Journal of…
2002
Corpus ID: 30765781
Ligand‐dependent endocytosis of the epidermal growth factor receptor (EGFR) involves recruitment of a ubiquitin ligase, and…
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