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hepatocyte differentiation

Known as: liver cell differentiation 
The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

liver development
regulation of hepatocyte differentiation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic… 
Highly Cited
2012
Highly Cited
2012
A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation.
BACKGROUND & AIMS Hepatocyte differentiation is controlled by liver-enriched transcription factors (LETFs). We investigated… 
Highly Cited
2011
Highly Cited
2011
Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors
The location and timing of cellular differentiation must be stringently controlled for proper organ formation. Normally… 
Highly Cited
2008
Highly Cited
2008
Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo
Objective: The hepatic integration of human adipose tissue derived mesenchymal stem cells (hAT-MSCs) in vivo with or without… 
Highly Cited
2008
Highly Cited
2008
Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling
Human embryonic stem cells (hESCs) are a valuable source of pluripotential primary cells. To date, however, their homogeneous… 
Highly Cited
2007
Highly Cited
2007
Human mesenchymal stem cells as a two-edged sword in hepatic regenerative medicine: engraftment and hepatocyte differentiation versus profibrogenic potential
Background and aim: Mesenchymal stem cells from bone marrow (MSCs) may have the potential to differentiate in vitro and in vivo… 
Review
2003
Review
2003
HNF4: A central regulator of hepatocyte differentiation and function
The coordinated expression of a large number of genes is required for hepatocyte differentiation and function of the adult liver… 
Highly Cited
2001
Highly Cited
2001
Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis
ABSTRACT The numerous functions of the liver are controlled primarily at the transcriptional level by the concerted actions of a… 
Highly Cited
2000
Highly Cited
2000
Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha.
HNF-4alpha is a transcription factor of the nuclear hormone receptor family that is expressed in the hepatic diverticulum at the… 
Review
1996
Review
1996
Liver‐enriched transcription factors and hepatocyte differentiation
Liver‐specific gene expression in adult hepatocytes relies on four families of evolutionary conserved transcription factors that… 
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