heparanase activity

Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. [PMID:10916150]
National Institutes of Health

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2012
2012
BACKGROUND A reduced heparan sulphate (HS) expression in the glomerular basement membrane of patients with overt diabetic… (More)
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2003
2003
Heparanase, a heparan sulfate-specific endo-beta-D-glucuronidase, plays an important role in tumor cell metastasis through the… (More)
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Highly Cited
2003
Highly Cited
2003
Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with… (More)
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Highly Cited
1999
Highly Cited
1999
Heparanase activity correlates with the metastatic potential of tumor cells. Moreover, the anti-metastatic effect of non-anti… (More)
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Highly Cited
1999
Highly Cited
1999
Inhibitors of tumor angiogenesis and metastasis are rapidly emerging as important new drug candidates for cancer therapy. To… (More)
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1998
1998
Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by activated platelets. Since the cleavage and… (More)
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1997
1997
Heparan sulphate (HS) is an important component of the extracellular matrix and the vasculature basal laminar which functions as… (More)
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1991
1991
This study was undertaken to identify a heparan sulfate (HS) degradation endoglycosidase (heparanase) in cultured endothelial… (More)
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Highly Cited
1990
Highly Cited
1990
Incubation of platelets, neutrophils, and lymphoma cells with Descemet's membranes of bovine corneas and with the extracellular… (More)
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