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heparanase activity

Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains. [PMID:10916150]
National Institutes of Health

Papers overview

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Highly Cited
2020
Highly Cited
2020
Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established… 
2015
2015
Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate side chains from their proteoglycans. Thereby, heparanase… 
Review
2008
Review
2008
The physicochemical characteristics of the glomerular capillary filtration membrane restrict the passage of macromolecules on the… 
Highly Cited
2003
Highly Cited
2003
Heparanase is an enzyme that cleaves heparan sulfate chains of proteoglycans, and its expression has been associated with… 
Highly Cited
2003
Highly Cited
2003
Heparanase, a heparan sulfate‐specific endo‐β‐D‐glucuronidase, plays an important role in tumor cell metastasis through the… 
Highly Cited
1999
Highly Cited
1999
Inhibitors of tumor angiogenesis and metastasis are rapidly emerging as important new drug candidates for cancer therapy. To… 
Highly Cited
1999
Highly Cited
1999
Heparanase activity correlates with the metastatic potential of tumor cells. Moreover, the anti‐metastatic effect of non‐anti… 
Highly Cited
1998
Highly Cited
1998
Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by activated platelets. Since the cleavage and… 
Highly Cited
1997
Highly Cited
1997
Heparan sulphate (HS) is an important component of the extracellular matrix and the vasculature basal laminar which functions as… 
Highly Cited
1990
Highly Cited
1990
Incubation of platelets, neutrophils, and lymphoma cells with Descemet's membranes of bovine corneas and with the extracellular…