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hemiasterlin

National Institutes of Health

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Oligopeptides

Papers overview

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2012
2012
Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor
SummaryHemiasterlins are cytotoxic tripeptides with antimicrotubule activity originally isolated from marine sponges. We have… 
2009
2009
Hemiasterlin Analogues with Unnatural Amino Acids at the N-Terminal and Their Inhibitory Activity on Tumor Cells
Hemiasterlin is a tripeptide with highly alkylated unnatural amino acids. It acts as a potent tumor cell growth inhibitor. From… 
2008
2008
Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin
Purpose: HTI-286 is a fully synthetic analogue of the natural tripeptide hemiasterlin that inhibits tubulin polymerization and… 
2005
2005
Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin.
A synthetic analogue of the tripeptide hemiasterlin, designated HTI-286, depolymerizes microtubules, is a poor substrate for P… 
2004
2004
Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability.
Hemiasterlins are sponge-derived tripeptides that inhibit cell growth by depolymerizing existing microtubules and inhibiting… 
2004
2004
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
2004
2004
D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors.
Highly Cited
2003
Highly Cited
2003
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
Hemiasterlin is a natural product derived from marine sponges that, like other structurally diverse peptide-like molecules, binds… 
2003
2003
Stability of drug-induced tubulin rings by fluorescence correlation spectroscopy.
Fluorescence correlation spectroscopy (FCS) was applied to investigate the stability of tubulin rings that result from the… 
Highly Cited
1999
Highly Cited
1999
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.
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