heme oxygenase (decyclizing) activity

Known as: haem oxygenase activity, heme oxidase activity, heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating) 
Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. [EC:1.14.99.3]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Bilirubin, an abundant pigment that causes jaundice, has long lacked any clear physiologic role. It arises from enzymatic… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Heme oxygenase-1 (HO-1) is a redox-sensitive inducible protein that provides efficient cytoprotection against oxidative stress… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Curcumin, a widely used spice and coloring agent in food, has been shown to possess potent antioxidant, antitumor promoting and… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Bilirubin is a potent antioxidant generated intracellularly during the degradation of heme by the enzyme heme oxygenase. The… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The stress protein heme oxygenase-1 (HO-1) is induced in endothelial cells exposed to nitric oxide (NO)-releasing agents, and… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The inducible isoform of haem oxygenase (HO-1) has been proposed as an effective system to counteract oxidant-induced cell injury… (More)
  • figure 1
  • figure 3
  • table 1
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Thiols are very important antioxidants that protect cells against oxidative insults. Recently, a different and new physiological… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
We investigated the effect of nitric oxide (NO) on the induction of the stress protein heme oxygenase and its protective role in… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Heme oxygenase-1 mRNA levels increase following exposure of many mammalian cell lines to oxidative stress such as ultraviolet A… (More)
Is this relevant?
Highly Cited
1987
Highly Cited
1987
A heat shock element is located in the 5'-flanking region of the rat heme oxygenase gene (HO gene). The incubation of rat glioma… (More)
Is this relevant?