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heme export

The directed movement of heme out of a cell or organelle. [GOC:lf, PMID:15369674, PMID:20610401]
National Institutes of Health

Papers overview

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2013
2013
RED CELLS , IRON , AND ERYTHROPOIESIS FLVCR is necessary for erythroid maturation , may contribute to platelet maturation , but is dispensable for normal hematopoietic stem cell function
Hematopoietic stem cells (HSCs) are defined by several properties: quiescence, self-renewal, and multilineage differentiation… 
2013
2013
Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity
2012
2012
Mitochondrial Heme Export Through FLVCR1b Controls Erythroid Differentiation.
Abstract 2090 Feline Leukemia Virus subgroup C Receptor 1 (FLVCR1) is a cell membrane heme exporter that contributes to maintain… 
2011
2011
FLVCR, a heme export protein, is required for T cell development beyond the CD4+CD8+ double-positive stage (64.18)
Heme is essential for every mammalian cell; however, free heme can induce free radical formation and cellular damage and cells… 
2009
2009
Loss of FLVCR, a Heme Export Protein, Blocks Thymic T Cell Development at the CD4+CD8+ Double-Positive Stage.
Abstract 913 Cats viremic with the feline leukemia virus C (FeLV-C) develop profound anemia with an early block in erythroid… 
2007
2007
Evidence That Heme Export Via the Feline Leukemia Virus, Subgroup, C Receptor (FLVCR) Is Carrier Dependent and Its Physiological Implications.
FLVCR is a heme export protein that is required for proerythroblast survival (Cell 18:757, 2004), macrophage heme-iron recycling… 
2007
2007
A Heme Export Protein Is Required for Red Cell Differentiation and Iron Homeostasis.
Heme is required by all aerobic cells, yet toxic, so its intracellular concentration must be tightly regulated. We previously… 
2006
2006
A Heme Export Protein Is Required for Red Cell Differentiation and May Facilitate Iron Homeostasis.
Heme is a component of cytochromes, catalases, glutathione peroxidase, hydroxylases, and nitric oxide synthase, as well as… 
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