FAQ

hSWI/SNF

Known as: Human SWI/SNF 
hSWI/SNF is an ATP-dependent chromatin-remodeling complex implicated in the regulation of gene expression, cell cycle control, and oncogenesis. The… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2017
024619942017

Related topics

Related topics

7 relations
AT-Rich Interactive Domain-Containing Protein 1BE-RC1SMARCA2 protein, humanSMARCB1 protein, human
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Related mentions per year

Related mentions per year

1986-2018
19801990200020102020
hSWI/SNF
SMARCB1 protein, human
SMARCD1 protein, human
SMARCD3 protein, human
SMARCA2 protein, human
SMARCD2 protein, human

Papers overview

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Highly Cited
2004
Highly Cited
2004
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.
Protein arginine methyltransferases (PRMTs) have been implicated in transcriptional activation and repression, but their role in… (More)
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Highly Cited
2000
Highly Cited
2000
Exit from G1 and S Phase of the Cell Cycle Is Regulated by Repressor Complexes Containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and the hSWI/SNF nucleosome remodeling… (More)
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Highly Cited
2000
Highly Cited
2000
BRCA1 Is Associated with a Human SWI/SNF-Related Complex Linking Chromatin Remodeling to Breast Cancer
Germline mutations in the tumor suppressor gene, BRCA1, predispose individuals to breast and ovarian cancers. Using a combination… (More)
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Highly Cited
2000
Highly Cited
2000
Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA.
The ordered assembly of immunoglobulin and TCR genes by V(D)J recombination depends on the regulated accessibility of individual… (More)
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Highly Cited
2000
Highly Cited
2000
A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex.
The SWI/SNF family of chromatin-remodeling complexes facilitates gene activation by assisting transcription machinery to gain… (More)
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Highly Cited
1999
Highly Cited
1999
Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.
Protein complexes of the SWI/SNF family remodel nucleosome structure in an ATP-dependent manner. Each complex contains between 8… (More)
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Highly Cited
1998
Highly Cited
1998
Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.
During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed… (More)
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Highly Cited
1998
Highly Cited
1998
Human SWI/SNF Interconverts a Nucleosome between Its Base State and a Stable Remodeled State
The human SWI/SNF complex remodels nucleosome structure in an ATP-dependent manner, although the nature of this change has not… (More)
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Highly Cited
1994
Highly Cited
1994
Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex.
CHROMATIN structure can affect the transcriptional activity of eukaryotic structural genes by blocking access of sequence… (More)
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Highly Cited
1994
Highly Cited
1994
Facilitated binding of TATA-binding protein to nucleosomal DNA.
BINDING of the TATA-binding protein (TBP) to the TATA box is required for transcription from many eukaryotic promoters in gene… (More)
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