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guanosine tetraphosphate biosynthetic process

Known as: guanosine tetraphosphate anabolism, guanosine tetraphosphate biosynthesis, guanosine tetraphosphate formation 
The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations.
RATIONALE Premature termination codons (PTCs) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic… Expand
2016
2016
New highly active antiplatelet agents with dual specificity for platelet P2Y1 and P2Y12 adenosine diphosphate receptors.
Currently approved platelet adenosine diphosphate (ADP) receptor antagonists target only the platelet P2Y12 receptor. Moreover… Expand
2007
2007
Crystal structure of tryptophanyl-tRNA synthetase complexed with adenosine-5' tetraphosphate: evidence for distributed use of catalytic binding energy in amino acid activation by class I aminoacyl…
Tryptophanyl-tRNA synthetase (TrpRS) is a functionally dimeric ligase, which specifically couples hydrolysis of ATP to AMP and… Expand
Highly Cited
2002
Highly Cited
2002
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms.
The crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1… Expand
Highly Cited
2001
Highly Cited
2001
Activity of diadenosine polyphosphates at P2Y receptors stably expressed in 1321N1 cells.
The selectivities of the diadenosine polyphosphates (Ap(n)As, n=2-6) at the human P2Y(1), P2Y(2), P2Y(4), P2Y(6) and P2Y(11… Expand
1999
1999
A new approach to the synthesis of branched and branched cyclic oligoribonucleotides
The six-step synthesis of the di-triethylammonium salt of 5[prime]-O -trityl-6-N-pivaloyladenosine-2[prime]-(H -phosphonate)-3… Expand
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Highly Cited
1991
Highly Cited
1991
AppppA binds to several proteins in Escherichia coli, including the heat shock and oxidative stress proteins DnaK, GroEL, E89, C45 and C40.
The dinucleotide AppppA (5′,5′″‐P1, P4‐diadenosine tetraphosphate) is rapidly synthesized in cells exposed to heat stress or… Expand
Highly Cited
1989
Highly Cited
1989
In vivo synthesis of adenylylated bis(5'-nucleosidyl) tetraphosphates (Ap4N) by Escherichia coli aminoacyl-tRNA synthetases.
The role of aminoacyl-tRNA synthetases in the in vivo synthesis of adenylylated bis(5'-nucleosidyl) tetraphosphates (Ap4N) was… Expand
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1985
1985
Molecular cloning of the Escherichia coli gene for diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase.
A clone overproducing diadenosine tetraphosphatase (diadenosine 5', 5'''-P1, P4-tetraphosphate pyrophosphohydrolase) activity was… Expand
Highly Cited
1968
Highly Cited
1968
Studies on the biosynthesis and role of diguanosine tetraphosphate during growth and development of Artemia salina.
Abstract Analysis of the acid-soluble fraction during growth and development of the brine shrimp, Artemia salina , using… Expand
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