growth factor receptor-bound protein 2

Known as: Abundant Src Homology Protein, GRB2 Adaptor Protein, Growth Factor Receptor Bound Protein 2 
GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced… (More)
National Institutes of Health

Papers overview

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2000
2000
The protein tyrosine phosphatase SHP-1 is predominantly expressed in hemopoietic cell lineages, where its function is relatively… (More)
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Highly Cited
2000
Highly Cited
2000
Regulation of the steady-state tyrosine phosphorylation of the insulin receptor and its postreceptor substrates are essential… (More)
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1998
1998
Growth factor receptor-bound protein-2 (GRB-2) is a protein linking receptor tyrosine kinase and Sos (Son of Sevenless gene; Ras… (More)
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Highly Cited
1994
Highly Cited
1994
INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1 receptor tyrosine kinases; it has an… (More)
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Highly Cited
1994
Highly Cited
1994
THE cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells… (More)
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Highly Cited
1994
Highly Cited
1994
Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr… (More)
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Highly Cited
1993
Highly Cited
1993
BCR-ABL is a chimeric oncoprotein that exhibits deregulated tyrosine kinase activity and is implicated in the pathogenesis of… (More)
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Highly Cited
1993
Highly Cited
1993
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… (More)
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Highly Cited
1993
Highly Cited
1993
Insulin-induced activation of extracellular signal-regulated kinases [ERKs, also known as mitogen-activated protein (MAP) kinases… (More)
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Highly Cited
1992
Highly Cited
1992
A cDNA clone encoding a novel, widely expressed protein (called growth factor receptor-bound protein 2 or GRB2) containing one… (More)
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