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growth factor receptor-bound protein 2

Known as: Abundant Src Homology Protein, GRB2 Adaptor Protein, Growth Factor Receptor Bound Protein 2 
GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced… Expand
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
Regulation of the steady-state tyrosine phosphorylation of the insulin receptor and its postreceptor substrates are essential… Expand
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Highly Cited
1994
Highly Cited
1994
THE cytoplasmic focal adhesion protein-tyrosine kinase (FAK) localizes with surface integrin receptors at sites where cells… Expand
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Highly Cited
1994
Highly Cited
1994
INSULIN receptor substrate-1 (IRS-1) is the major substrate of insulin receptor and IGF-1 receptor tyrosine kinases; it has an… Expand
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Highly Cited
1994
Highly Cited
1994
Src homology 2 (SH2) domains provide specificity to intracellular signaling by binding to specific phosphotyrosine (phospho-Tyr… Expand
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Highly Cited
1994
Highly Cited
1994
Autophosphorylated growth factor receptors provide binding sites for the src homology 2 domains of intracellular signaling… Expand
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Highly Cited
1993
Highly Cited
1993
BCR-ABL is a chimeric oncoprotein that exhibits deregulated tyrosine kinase activity and is implicated in the pathogenesis of… Expand
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Highly Cited
1993
Highly Cited
1993
A human complementary DNA was isolated that encodes a widely expressed protein, hSos1, that is closely related to Sos, the… Expand
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Highly Cited
1993
Highly Cited
1993
GRB2, a small protein comprising one SH2 domain and two SH3 domains, represents the human homologue of the Caenorhabditis elegans… Expand
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Highly Cited
1993
Highly Cited
1993
Insulin-induced activation of extracellular signal-regulated kinases [ERKs, also known as mitogen-activated protein (MAP) kinases… Expand
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Highly Cited
1992
Highly Cited
1992
A cDNA clone encoding a novel, widely expressed protein (called growth factor receptor-bound protein 2 or GRB2) containing one… Expand
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