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gp96 heat shock protein-peptide complex

Known as: Autologous gp96 Heat Shock Protein Peptide Complex Vaccine, gp96 heat shock protein-peptide complex vaccine, gp96 HSP-Peptide Complex 
A vaccine made from a patient's tumor cells that may help the body's immune system kill cancer cells. This vaccine is used to treat kidney cancer, a… 
National Institutes of Health

Related topics

Related topics

4 relations

Narrower (2)

HSPPC-96Oncophage

Broader (1)

Heat shock proteins
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain*
Background: gp96 is a molecular chaperone that binds and chaperones TLRs and integrins. But the structural basis of such is… 
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Highly Cited
2009
Highly Cited
2009
Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway1
Extracellular heat shock proteins (HSP) can activate dendritic cells (DC) and monocytes/macrophages, and HSP derived from tumor… 
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Highly Cited
2008
Highly Cited
2008
Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.
PURPOSE To assess the antitumor activity of vitespen (autologous, tumor- derived heat shock protein gp96 peptide complexes) by… 
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Review
2008
Review
2008
An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label…
BACKGROUND Treatment of localised renal cell carcinoma consists of partial or radical nephrectomy. A substantial proportion of… 
Highly Cited
2005
Highly Cited
2005
Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein
By comparative genomics, we have identified a gene of the intracellular pathogen Listeria monocytogenes that encodes an LPXTG… 
Highly Cited
2005
Highly Cited
2005
Maximum likelihood estimation of covariance parameters for Bayesian atmospheric trace gas surface flux inversions
[1] This paper introduces a Maximum Likelihood (ML) approach for estimating the statistical parameters required for the… 
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Highly Cited
2004
Highly Cited
2004
Essential role of CD91 in re-presentation of gp96-chaperoned peptides.
Heat shock proteins (HSPs) such as gp96 are released from cells as a result of necrotic cell death. The ability of endogenous HSP… 
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Highly Cited
2003
Highly Cited
2003
Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer.
PURPOSE Heat shock proteins (HSP) from tumor cells contain the gp96 polypeptide associated with cancer-specific antigenic… 
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Highly Cited
2000
Highly Cited
2000
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway.
Dendritic cells (DC) are key components of innate and adaptive immune responses. The identity of endogenous signals that activate… 
Highly Cited
1998
Highly Cited
1998
Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression.
BACKGROUND Recent evidence has implicated Chlamydia pneumoniae in the aggravation of atherosclerosis. However, the mechanisms by… 
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