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gp96 heat shock protein-peptide complex
Known as:
Autologous gp96 Heat Shock Protein Peptide Complex Vaccine
, gp96 heat shock protein-peptide complex vaccine
, gp96 HSP-Peptide Complex
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A vaccine made from a patient's tumor cells that may help the body's immune system kill cancer cells. This vaccine is used to treat kidney cancer, a…
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National Institutes of Health
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Related topics
Related topics
4 relations
Narrower (2)
HSPPC-96
Oncophage
Broader (1)
Heat shock proteins
NCIt Antineoplastic Agent Terminology
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain*
Shuang Wu
,
F. Hong
,
D. Gewirth
,
B. Guo
,
Bei Liu
,
Zihai Li
Journal of Biological Chemistry
2012
Corpus ID: 14087152
Background: gp96 is a molecular chaperone that binds and chaperones TLRs and integrins. But the structural basis of such is…
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Highly Cited
2009
Highly Cited
2009
Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway1
Taoyong Chen
,
Jun Guo
,
Chaofeng Han
,
Mingjin Yang
,
Xuetao Cao
Journal of Immunology
2009
Corpus ID: 2362422
Extracellular heat shock proteins (HSP) can activate dendritic cells (DC) and monocytes/macrophages, and HSP derived from tumor…
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Highly Cited
2008
Highly Cited
2008
Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.
A. Testori
,
J. Richards
,
+10 authors
P. Srivastava
Journal of Clinical Oncology
2008
Corpus ID: 7949357
PURPOSE To assess the antitumor activity of vitespen (autologous, tumor- derived heat shock protein gp96 peptide complexes) by…
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Review
2008
Review
2008
An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label…
C. Wood
,
P. Srivastava
,
+12 authors
B. Escudier
The Lancet
2008
Corpus ID: 37582272
Highly Cited
2005
Highly Cited
2005
Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein
D. Cabanes
,
Sandra Sousa
,
A. Cebriá
,
Marc Lecuit
,
F. García-del Portillo
,
P. Cossart
EMBO Journal
2005
Corpus ID: 26291512
By comparative genomics, we have identified a gene of the intracellular pathogen Listeria monocytogenes that encodes an LPXTG…
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Highly Cited
2005
Highly Cited
2005
Maximum likelihood estimation of covariance parameters for Bayesian atmospheric trace gas surface flux inversions
A. Michalak
,
A. Hirsch
,
+5 authors
P. Tans
2005
Corpus ID: 30268696
[1] This paper introduces a Maximum Likelihood (ML) approach for estimating the statistical parameters required for the…
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Highly Cited
2004
Highly Cited
2004
Essential role of CD91 in re-presentation of gp96-chaperoned peptides.
R. Binder
,
Pramod K Srivastava
Proceedings of the National Academy of Sciences…
2004
Corpus ID: 205238079
Heat shock proteins (HSPs) such as gp96 are released from cells as a result of necrotic cell death. The ability of endogenous HSP…
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Highly Cited
2003
Highly Cited
2003
Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer.
V. Mazzaferro
,
J. Coppa
,
+12 authors
G. Parmiani
Clinical Cancer Research
2003
Corpus ID: 12715765
PURPOSE Heat shock proteins (HSP) from tumor cells contain the gp96 polypeptide associated with cancer-specific antigenic…
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Highly Cited
2000
Highly Cited
2000
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappa B pathway.
S. Basu
,
R. Binder
,
R. Suto
,
K. M. Anderson
,
P. Srivastava
International Immunology
2000
Corpus ID: 32254046
Dendritic cells (DC) are key components of innate and adaptive immune responses. The identity of endogenous signals that activate…
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Highly Cited
1998
Highly Cited
1998
Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression.
A. Kol
,
G. Sukhova
,
A. Lichtman
,
P. Libby
Circulation
1998
Corpus ID: 7530772
BACKGROUND Recent evidence has implicated Chlamydia pneumoniae in the aggravation of atherosclerosis. However, the mechanisms by…
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