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glyoxalase (glycolic acid-forming) activity

Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor. [GOC:bf, GOC:PARL, PMID:22523093]
National Institutes of Health

Papers overview

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2015
2015
It has been reported that many malignant human tissues, including breast, colon, and lung cancers, may show an elevated… 
Highly Cited
2012
Highly Cited
2012
Aim:  Metformin plays an important role in the inhibition of cancer cell growth and prolongs remission durations. It reverses… 
Highly Cited
2010
Highly Cited
2010
Introduction: A long-term treatment with progestin commonly results in progestin resistance in endometrial cancer. So, the aim of… 
2001
2001
Abstract.Aims/hypothesis: The hyperglycaemia associated with diabetes causes excessive production of cytotoxic methylglyoxal, an… 
2000
2000
The proposed rate-limiting step of the glyoxalase I catalyzed reaction is the proton abstraction from the C1 carbon of the… 
Highly Cited
1998
Highly Cited
1998
3D domain swapping of proteins involves the interconversion of a monomer containing a single domain-domain interface and a 2-fold… 
Highly Cited
1961
Highly Cited
1961
Barker, H. A., Weissbach, H. & Smyth, R. D. (1958). Proc. nat. Acad. Sci., Wash., 44, 1093. Biserte, G. & Osteux, R. (1951). Bull…