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glyoxalase (glycolic acid-forming) activity

Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor. [GOC:bf, GOC:PARL, PMID:22523093]
National Institutes of Health

Papers overview

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2015
2015
It has been reported that many malignant human tissues, including breast, colon, and lung cancers, may show an elevated… Expand
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Highly Cited
2012
Highly Cited
2012
Aim:  Metformin plays an important role in the inhibition of cancer cell growth and prolongs remission durations. It reverses… Expand
Highly Cited
2010
Highly Cited
2010
Introduction: A long-term treatment with progestin commonly results in progestin resistance in endometrial cancer. So, the aim of… Expand
2009
2009
The glyoxalase system catalyzes the conversion of toxic methylglyoxal to nontoxic d-lactic acid using glutathione (GSH) as a… Expand
2008
2008
Glyoxalase I (GLO I) is the rate-limiting enzyme for detoxification of methylglyoxal (MG), a side product of glycolysis, which is… Expand
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2001
2001
Abstract.Aims/hypothesis: The hyperglycaemia associated with diabetes causes excessive production of cytotoxic methylglyoxal, an… Expand
2000
2000
The proposed rate-limiting step of the glyoxalase I catalyzed reaction is the proton abstraction from the C1 carbon of the… Expand
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Highly Cited
1998
Highly Cited
1998
3D domain swapping of proteins involves the interconversion of a monomer containing a single domain-domain interface and a 2-fold… Expand
Highly Cited
1994
Highly Cited
1994
S-p-Bromobenzylglutathione diethyl ester induced toxicity in the malarial parasite Plasmodium falciparum in infected human red… Expand
Highly Cited
1961