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glycosphingolipid biosynthetic process

Known as: glycosphingolipid biosynthesis, glycosphingolipid anabolism, glycosphingolipid synthesis 
The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Inhibition of Glycosphingolipid Synthesis Ameliorates Atherosclerosis and Arterial Stiffness in Apolipoprotein E−/− Mice and Rabbits Fed a High-Fat and -Cholesterol Diet
Background— Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing… Expand
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Highly Cited
2009
Highly Cited
2009
Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation
Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological… Expand
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Highly Cited
2007
Highly Cited
2007
Inhibiting Glycosphingolipid Synthesis Improves Glycemic Control and Insulin Sensitivity in Animal Models of Type 2 Diabetes
Previous reports have shown that glycosphingolipids can modulate the activity of the insulin receptor, and studies in transgenic… Expand
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Highly Cited
2007
Highly Cited
2007
Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
Glycosphingolipids are controlled by the spatial organization of their metabolism and by transport specificity. Using… Expand
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Highly Cited
2005
Highly Cited
2005
Egghead and Brainiac Are Essential for Glycosphingolipid Biosynthesis in Vivo*
The Drosophila genes, brainiac and egghead, encode glycosyltransferases predicted to act sequentially in early steps of… Expand
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Highly Cited
2004
Highly Cited
2004
Role of Multiple Drug Resistance Protein 1 in Neutral but Not Acidic Glycosphingolipid Biosynthesis*
Transfection studies have implicated the multiple drug resistance pump, MDR1, as a glucosyl ceramide translocase within the Golgi… Expand
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Review
2000
Review
2000
[A vital role for glycosphingolipid synthesis during development and differentiation].
  • T. Yamashita
  • Seikagaku. The Journal of Japanese Biochemical…
  • 2000
    • Corpus ID: 12664844
Glycosphingolipids (GSLs) are believed to be integral for the dynamics of many cell membrane events, including cellular… Expand
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Highly Cited
1998
Highly Cited
1998
Functional Organization of the Golgi Apparatus in Glycosphingolipid Biosynthesis
Biosynthesis of plasma membrane sphingolipids involves the coordinate action of enzymes localized to individual compartments of… Expand
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Highly Cited
1996
Highly Cited
1996
Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis.
We have isolated a cDNA encoding human ceramide glucosyltransferase (glucosylceramide synthase, UDP-glucose:N-acylsphingosine D… Expand
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Highly Cited
1996
Highly Cited
1996
Topology of sphingolipid galactosyltransferases in ER and Golgi: transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis
Glucosylceramide (GlcCer) is synthesized at the cytosolic surface of the Golgi complex while enzymes acting in late steps of… Expand
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