glycosphingolipid biosynthetic process

Known as: glycosphingolipid biosynthesis, glycosphingolipid anabolism, glycosphingolipid synthesis 
The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one… (More)
National Institutes of Health

Papers overview

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2014
2014
Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-/- mice and rabbits fed a high-fat and -cholesterol diet.
BACKGROUND Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing… (More)
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2009
2009
Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation
Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological… (More)
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2009
2009
Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.
UNLABELLED Steatosis in the liver is a common feature of obesity and type 2 diabetes and the precursor to the development of… (More)
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Highly Cited
2007
Highly Cited
2007
Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes.
Previous reports have shown that glycosphingolipids can modulate the activity of the insulin receptor, and studies in transgenic… (More)
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Highly Cited
2005
Highly Cited
2005
Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.
Alzheimer disease is associated with extracellular deposits of amyloid beta-peptides in the brain. Amyloid beta-peptides are… (More)
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2004
2004
Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis.
Transfection studies have implicated the multiple drug resistance pump, MDR1, as a glucosyl ceramide translocase within the Golgi… (More)
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Highly Cited
1999
Highly Cited
1999
A vital role for glycosphingolipid synthesis during development and differentiation.
Glycosphingolipids (GSLs) are believed to be integral for the dynamics of many cell membrane events, including cellular… (More)
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1998
1998
Functional organization of the Golgi apparatus in glycosphingolipid biosynthesis. Lactosylceramide and subsequent glycosphingolipids are formed in the lumen of the late Golgi.
Biosynthesis of plasma membrane sphingolipids involves the coordinate action of enzymes localized to individual compartments of… (More)
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Highly Cited
1996
Highly Cited
1996
Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis.
 
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1996
1996
Topology of sphingolipid galactosyltransferases in ER and Golgi: transbilayer movement of monohexosyl sphingolipids is required for higher glycosphingolipid biosynthesis
Glucosylceramide (GlcCer) is synthesized at the cytosolic surface of the Golgi complex while enzymes acting in late steps of… (More)
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