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glutathione S-conjugate-exporting ATPase activity

Known as: ATP-dependent glutathione S-conjugate export pump, GS-X pump, MRP1/GS-X pump 
Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out). [GOC:jl, PMID:1455517]
National Institutes of Health

Papers overview

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2012
2012
Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP) is critically involved in multidrug resistance of human cancer. This… Expand
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Highly Cited
2004
Highly Cited
2004
The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase… Expand
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2004
2004
The biological function as well as gene expression of the MRP/GS-X pump is closely linked with cellular GSH metabolism. This… Expand
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Review
1998
Review
1998
Glutathione conjugation and transport of glutathione conjugates of anticancer drugs out of cells have been shown to work as a… Expand
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Review
1998
Review
1998
It has been shown that both multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion… Expand
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Highly Cited
1995
Highly Cited
1995
The ATP-dependent glutathione S-conjugate export pump (GS-X pump) has been suggested to play a role in the mechanism of cisplatin… Expand
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