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glutamate carboxypeptidase II, human

Known as: PSMA antigen, Glutamate Carboxypeptidase II, Prostate-Specific Membrane Antigen 
Glutamate carboxypeptidase 2 (750 aa, ~84 kDa) is encoded by the human FOLH1 gene. This protein plays a role in the mediation of folate metabolism.
National Institutes of Health

Related topics

Related topics

13 relations
Enzyme GeneFOLH1 geneFOLH1 wt AlleleHydrolysis

Broader (2)

Glutamate Carboxypeptidase IISurface Antigens

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Sensitivity, Specificity, and Predictors of Positive 68Ga-Prostate-specific Membrane Antigen Positron Emission Tomography in Advanced Prostate Cancer: A Systematic Review and Meta-analysis.
Highly Cited
2016
Highly Cited
2016
Simultaneous 68Ga-PSMA HBED-CC PET/MRI Improves the Localization of Primary Prostate Cancer.
Highly Cited
2015
Highly Cited
2015
Prospective Comparison of 18F-Fluoromethylcholine Versus 68Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Targeted Therapy
In prostate cancer with biochemical failure after therapy, current imaging techniques have a low detection rate at the prostate… 
Review
2012
Review
2012
Redox activation of metal-based prodrugs as a strategy for drug delivery.
Highly Cited
2010
Highly Cited
2010
A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer.
Computed tomography (CT) is one of the most useful diagnostic tools among commonly used biomedical imaging techniques, which also… 
Highly Cited
2009
Highly Cited
2009
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have been targeted with RNA aptamer–small interfering… 
Highly Cited
2008
Highly Cited
2008
Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization.
Urea-based, low molecular weight ligands of glutamate carboxypeptidase II (GCPII) have demonstrated efficacy in various models of… 
Highly Cited
2005
Highly Cited
2005
Phase I trial of 177lutetium-labeled J591, a monoclonal antibody to prostate-specific membrane antigen, in patients with androgen-independent prostate cancer.
PURPOSE To determine the maximum tolerated dose (MTD), toxicity, human anti-J591 response, pharmacokinetics (PK), organ dosimetry… 
Highly Cited
1997
Highly Cited
1997
Betaine improves the PCR amplification of GC-rich DNA sequences.
Betaine improves the co-amplification of the two alternatively spliced variants of the prostate-specific membrane antigen mRNA as… 
Highly Cited
1996
Highly Cited
1996
Upregulation of prostate-specific membrane antigen after androgen-deprivation therapy.
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