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glucosylceramidase activity

Known as: ceramide glucosidase activity, glucosylsphingosine beta-glucosidase activity, acid beta-glucosidase activity 
Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. [EC:3.2.1.45]
National Institutes of Health

Related topics

Related topics

2 relations
negative regulation of glucosylceramidase activitypositive regulation of glucosylceramidase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
New Therapeutic Strategies for Lewy Body Dementias
This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available… 
Highly Cited
1996
Highly Cited
1996
Induction of Ceramide Glucosyltransferase Activity in Cultured Human Keratinocytes
Ceramides are the major component of the extracellular lipids that comprise the epidermal permeability barrier. They are derived… 
1994
1994
Transduction of CD34+ enriched cord blood and Gaucher bone marrow cells by a retroviral vector carrying the glucocerebrosidase gene.
One promising strategy for gene therapy of Gaucher disease involves ex vivo retroviral transduction of autologous hematopoietic… 
Highly Cited
1992
Highly Cited
1992
High levels of human glucocerebrosidase activity in macrophages of long-term reconstituted mice after retroviral infection of hematopoietic stem cells.
Gaucher disease is a leading candidate for somatic gene therapy using bone marrow (BM) cells as target tissue. Towards this end… 
1986
1986
Purification of human placental glucocerebrosidase using a two-step high-performance hydrophobic and gel permeation column chromatography method.
Highly Cited
1984
Highly Cited
1984
Synthesis of a fluorescent derivative of glucosyl ceramide for the sensitive determination of glucocerebrosidase activity.
1984
1984
Activators of spleen glucocerebrosidase from controls and patients with various forms of Gaucher's disease.
1984
1984
Calmodulin and parvalbumin: activators of human liver glucocerebrosidase.
1980
1980
A revised fluorometric assay for Gaucher's disease using conduritol-beta-epoxide with liver as the source of Beta-glucosidase.
1976
1976
Effects of detergents and choline-containing phospholipids on human spleen glucocerebrosidase.
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