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germinal center formation

The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid… Expand
National Institutes of Health

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Highly Cited
2016
Highly Cited
2016
B cell–intrinsic IFN-γ receptor signaling through STAT1 is required for the generation of spontaneous germinal centers, which can… Expand
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Highly Cited
2013
Highly Cited
2013
The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and targeted by somatic mutations in B… Expand
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Highly Cited
2012
Highly Cited
2012
B cells require MHC class II (MHC II)-restricted cognate help and CD40 engagement by CD4+ T follicular helper (TFH) cells to form… Expand
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Highly Cited
2011
Highly Cited
2011
Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper… Expand
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Highly Cited
2005
Highly Cited
2005
ABSTRACT BTB-kelch proteins can elicit diverse biological functions but very little is known about the physiological role of… Expand
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Highly Cited
2005
Highly Cited
2005
It has been demonstrated previously that platelet-derived CD154 communicates with the adaptive immune compartment, enhancing B… Expand
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Highly Cited
1997
Highly Cited
1997
Humoral immune responses were characterized in mouse strains lacking either or both B7 molecules. Mice deficient in both B7-1 and… Expand
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Highly Cited
1996
Highly Cited
1996
Previous studies have demonstrated that the T cell costimulatory molecule, CD28, is important in the development of humoral… Expand
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Highly Cited
1994
Highly Cited
1994
An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known to provide an essential costimulatory… Expand
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Highly Cited
1994
Highly Cited
1994
gp39, the ligand for CD40 expressed on activated CD4+ T helper cells, is required for the generation of antibody responses to T… Expand
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