genetic linkage analysis

Known as: analysis linkage, Linkage Analysis, Genetic, Genetic Linkage Analyses 
A gene-hunting technique that traces patterns of disease in high-risk families. It attempts to locate a disease-causing gene by identifying genetic… (More)

Topic mentions per year

Topic mentions per year

1957-2018
010020030019572017

Papers overview

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Highly Cited
2000
Highly Cited
2000
nature genetics • volume 25 • may 2000 125 NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive… (More)
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Highly Cited
1998
Highly Cited
1998
Multipoint linkage analysis of quantitative-trait loci (QTLs) has previously been restricted to sibships and small pedigrees. In… (More)
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Highly Cited
1998
Highly Cited
1998
Prior to performance of linkage analysis, elimination of all Mendelian inconsistencies in the pedigree data is essential. Often… (More)
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Highly Cited
1997
Highly Cited
1997
A new method for segregation and linkage analysis, with pedigree data, is described. Reversible jump Markov chain Monte Carlo… (More)
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Highly Cited
1996
Highly Cited
1996
In complex disease studies, it is crucial to perform multipoint linkage analysis with many markers and to use robust… (More)
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Highly Cited
1994
Highly Cited
1994
We describe four improvements we have implemented in a version of the genetic linkage analysis programs in the LINKAGE package… (More)
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Highly Cited
1993
Highly Cited
1993
Breast cancer is known to have an inherited component, consistent in some families with autosomal dominant inheritance; in such… (More)
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Highly Cited
1987
Highly Cited
1987
With the advent of RFLPs, genetic linkage maps are now being assembled for a number of organisms including both inbred… (More)
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Highly Cited
1985
Highly Cited
1985
Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different… (More)
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Highly Cited
1984
Highly Cited
1984
The increasing number of DNA polymorphisms characterized in humans will soon allow the construction of fine genetic maps of human… (More)
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