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gemcitabine/tipifarnib

Known as: Gemcitabine/R115777, dFdC/R115777 
 
National Institutes of Health

Papers overview

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2007
2007
Zoledronic acid (ZOL) has proved activity in bone metastases from prostate cancer through inhibition of mevalonate pathway and of… Expand
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2007
2007
Cross-talk between receptor tyrosine kinases and estrogen receptor is at least partly responsible for the development of acquired… Expand
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2007
2007
Interferon alpha (IFNalpha) induces an EGF-Ras-->Raf-1-->Erk dependent survival pathway counteracting apoptosis induced by the… Expand
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2007
2007
Cross-talk between receptor tyrosine kinases and estrogen receptor is at least partly responsible for the development of acquired… Expand
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2006
2006
8014 Background: Ras-based signaling is thought to be critical in the genesis of melanoma. Farneslytransferase (FT) inhibitors… Expand
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2005
2005
The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM… Expand
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2004
2004
Ras activation is frequently observed in multiple myeloma either by mutation or through interleukin-6 receptor signaling… Expand
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2003
2003
PURPOSE Inhibitors of farnesyltransferase (e.g., R115777) are being developed for therapy and prevention of various cancers. The… Expand
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Review
2001
Review
2001
Farnesyltransferase inhibitors represent a new class of agents that target signal transduction pathways responsible for the… Expand
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