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In this randomized, double-blind, placebo-controlled study comparing gemcitabine+tipifarnib (G+t) or gemcitabine+placebo (G+p) in… Expand Zoledronic acid (ZOL) has proved activity in bone metastases from prostate cancer through inhibition of mevalonate pathway and of… Expand Cross-talk between receptor tyrosine kinases and estrogen receptor is at least partly responsible for the development of acquired… Expand Interferon α (IFNα) induces an EGF‐Ras→Raf‐1→Erk dependent survival pathway counteracting apoptosis induced by the cytokine. In… Expand Cross-talk between receptor tyrosine kinases and estrogen receptor is at least partly responsible for the development of acquired… Expand The high incidence of activating RAS mutations, coupled with accumulating evidence linking RAS to multiple myeloma (MM… Expand Ras activation is frequently observed in multiple myeloma either by mutation or through interleukin-6 receptor signaling… Expand PURPOSE
Inhibitors of farnesyltransferase (e.g., R115777) are being developed for therapy and prevention of various cancers. The… Expand Farnesyltransferase inhibitors represent a new class of agents that target signal transduction pathways responsible for the… Expand