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gardiquimod

 
National Institutes of Health

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2 relations

Broader (2)

AminoquinolinesImidazoles

Papers overview

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2015
2015
TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is a common cancer worldwide and the third leading cause of cancer death. Immunotherapy is… Expand
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2013
2013
A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening.
Large-scale experimentation is becoming instrumental in enabling new discoveries in systems biology and personalized medicine. We… Expand
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Highly Cited
2012
Highly Cited
2012
Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes.
While current subunit vaccines successfully induce humoral immune responses, a need exists for vaccine strategies to elicit… Expand
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2012
2012
Intranasal Vaccination with Murabutide Enhances Humoral and Mucosal Immune Responses to a Virus-Like Particle Vaccine
Murabutide (MB) is a synthetic immunomodulator recognized by the nucleotide-binding oligomerization domain-containing protein 2… Expand
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Highly Cited
2011
Highly Cited
2011
Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine.
The development of a vaccine to prevent norovirus infections has been focused on immunization at a mucosal surface, but has been… Expand
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2011
2011
NTPDase1 controls IL-8 production by human neutrophils.
The ectonucleotidase NTPDase1 (CD39) terminates P2 receptor activation by the hydrolysis of extracellular nucleotides (i.e., the… Expand
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2010
2010
The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice
Toll-like receptors (TLRs) are a family of highly conserved germline-encoded pattern-recognition receptors that are essential for… Expand
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Highly Cited
2010
Highly Cited
2010
Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells.
Plasmacytoid dendritic cells (pDCs) play essential roles in directing immune responses. These cells may be particularly important… Expand
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Highly Cited
2009
Highly Cited
2009
Intradermal immunization improves protective efficacy of a novel TB vaccine candidate.
We have developed the Mycobacterium tuberculosis (Mtb) fusion protein (ID83), which contains the three Mtb proteins Rv1813… Expand
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Highly Cited
2008
Highly Cited
2008
Double-stranded RNA induces an antiviral defense status in epidermal keratinocytes through TLR3-, PKR-, and MDA5/RIG-I-mediated differential signaling.
Emerging evidence suggests an important role for human epidermal keratinocytes in innate immune mechanisms against bacterial and… Expand
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