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gamma-secretase complex

Known as: gamma-secretase complex location (APH1A, PSEN1, PSENEN, NCSTN variant), gamma-secretase complex location (APH1B, PSEN1, PSENEN, NCSTN), gamma-secretase complex location (APH1B, PSEN2, PSENEN, NCSTN) 
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
The β secretase, widely known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), initiates the production of the… Expand
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Highly Cited
2006
Highly Cited
2006
Mutations in human presenilin (PS) genes cause aggressive forms of familial Alzheimer's disease. Presenilins are polytopic… Expand
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Highly Cited
2005
Highly Cited
2005
The sequential enzymatic actions of β-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the γ-secretase… Expand
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Highly Cited
2004
Highly Cited
2004
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides… Expand
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Review
2003
Review
2003
Gamma-Secretase cleaves the Amyloid Precursor Protein (APP) in its transmembrane domain, releasing the amyloid peptide Abeta… Expand
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Highly Cited
2003
Highly Cited
2003
Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD). Presenilin… Expand
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Highly Cited
2003
Highly Cited
2003
Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer… Expand
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Highly Cited
2002
Highly Cited
2002
Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the gamma-secretase complex, and APP CTFbeta… Expand
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Highly Cited
2002
Highly Cited
2002
The Alzheimer disease-associated presenilin (PS) proteins apparently provide the active site of γ-secretase, an unusual… Expand
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Highly Cited
2002
Highly Cited
2002
In the brain of Alzheimer's disease (AD) patients, neurotoxic amyloid peptides accumulate and are deposited as senile plaques. A… Expand
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