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gamma-secretase complex

Known as: gamma-secretase complex location (APH1A, PSEN1, PSENEN, NCSTN variant), gamma-secretase complex location (APH1B, PSEN1, PSENEN, NCSTN), gamma-secretase complex location (APH1B, PSEN2, PSENEN, NCSTN) 
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of… 
National Institutes of Health

Papers overview

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2008
2008
γ-Secretase is an intramembrane cleaving aspartyl protease complex intimately implicated in Alzheimer disease pathogenesis. The… 
Review
2008
Review
2008
Mutations in two genes, presenilin 1 (PS1) and its homologue presenilin 2 (PS2), account for a majority of early onset familial… 
2008
2008
The presenilin‐associated complex regulates two independent intramembranous cleavage activities, i.e. γ‐secretase and ε‐secretase… 
Review
2007
Review
2007
Inhibition of the production of insoluble amyloid-Beta (ABeta) is a widely pursued strategy for the treatment of Alzheimer's… 
2006
2006
ABSTRACT Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's β-amyloid precursor protein (APP… 
2006
2006
Gamma-secretase is a founding member of membrane-embedded aspartyl proteases that cleave substrates within transmembrane domains… 
2005
2005
γ‐Secretase is an aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane… 
Review
2004
Review
2004
gamma-Secretase is a critical enzyme involved in the production of amyloid-beta (Abeta) peptide, one of the main pathological… 
2004
2004
Familial Alzheimer's disease mutations in the presenilin 1 gene (PSEN1) have been previously shown to potentiate caspase…