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gamma-secretase complex
Known as:
gamma-secretase complex location (APH1A, PSEN1, PSENEN, NCSTN variant)
, gamma-secretase complex location (APH1B, PSEN1, PSENEN, NCSTN)
, gamma-secretase complex location (APH1B, PSEN2, PSENEN, NCSTN)
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A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer’s Disease
J. Chu
,
Jian-guo Li
,
+4 authors
D. Praticò
Biological Psychiatry
2015
Corpus ID: 25578439
2008
2008
Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1*
H. Steiner
,
E. Winkler
,
C. Haass
Journal of Biological Chemistry
2008
Corpus ID: 42376095
γ-Secretase is an intramembrane cleaving aspartyl protease complex intimately implicated in Alzheimer disease pathogenesis. The…
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Review
2008
Review
2008
From presenilinase to gamma-secretase, cleave to capacitate.
W. Xia
Current Alzheimer Research
2008
Corpus ID: 21262504
Mutations in two genes, presenilin 1 (PS1) and its homologue presenilin 2 (PS2), account for a majority of early onset familial…
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2008
2008
TMP21 degradation is mediated by the ubiquitin‐proteasome pathway
Shengchun Liu
,
K. Bromley‐Brits
,
K. Xia
,
Jill Mittelholtz
,
Ruitao Wang
,
Weihong Song
European Journal of Neuroscience
2008
Corpus ID: 10375953
The presenilin‐associated complex regulates two independent intramembranous cleavage activities, i.e. γ‐secretase and ε‐secretase…
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Review
2007
Review
2007
Advances in gamma-secretase modulation.
Dmitri A Pissarnitski
Current opinion in drug discovery & development
2007
Corpus ID: 22619231
Inhibition of the production of insoluble amyloid-Beta (ABeta) is a widely pursued strategy for the treatment of Alzheimer's…
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2006
2006
Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREB
Ruishan Wang
,
Yun-wu Zhang
,
+7 authors
Zhuohua Zhang
Molecular and Cellular Biology
2006
Corpus ID: 24561105
ABSTRACT Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's β-amyloid precursor protein (APP…
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2006
2006
Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.
A. Kornilova
,
Jennifer Kim
,
Hanna Laudon
,
M. Wolfe
Biochemistry
2006
Corpus ID: 23121702
Gamma-secretase is a founding member of membrane-embedded aspartyl proteases that cleave substrates within transmembrane domains…
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2005
2005
Length and overall sequence of the PEN‐2 C‐terminal domain determines its function in the stabilization of presenilin fragments
S. Prokop
,
C. Haass
,
H. Steiner
Journal of Neurochemistry
2005
Corpus ID: 46193553
γ‐Secretase is an aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane…
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Review
2004
Review
2004
gamma-Secretase as a target for drug intervention in Alzheimer's disease.
T. Harrison
,
I. Churcher
,
D. Beher
Current opinion in drug discovery & development
2004
Corpus ID: 349264
gamma-Secretase is a critical enzyme involved in the production of amyloid-beta (Abeta) peptide, one of the main pathological…
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2004
2004
Effects of RNA Interference-mediated Silencing of γ-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation*
Zhongcong Xie
,
D. Romano
,
D. Kovacs
,
R. Tanzi
Journal of Biological Chemistry
2004
Corpus ID: 20203293
Familial Alzheimer's disease mutations in the presenilin 1 gene (PSEN1) have been previously shown to potentiate caspase…
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