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gamma-secretase complex

Known as: gamma-secretase complex location (APH1A, PSEN1, PSENEN, NCSTN variant), gamma-secretase complex location (APH1B, PSEN1, PSENEN, NCSTN), gamma-secretase complex location (APH1B, PSEN2, PSENEN, NCSTN) 
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of… 
National Institutes of Health

Papers overview

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2015
2015
Gamma Secretase-Activating Protein Is a Substrate for Caspase-3: Implications for Alzheimer’s Disease
2008
2008
Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1*
γ-Secretase is an intramembrane cleaving aspartyl protease complex intimately implicated in Alzheimer disease pathogenesis. The… 
Review
2008
Review
2008
From presenilinase to gamma-secretase, cleave to capacitate.
Mutations in two genes, presenilin 1 (PS1) and its homologue presenilin 2 (PS2), account for a majority of early onset familial… 
2008
2008
TMP21 degradation is mediated by the ubiquitin‐proteasome pathway
The presenilin‐associated complex regulates two independent intramembranous cleavage activities, i.e. γ‐secretase and ε‐secretase… 
Review
2007
Review
2007
Advances in gamma-secretase modulation.
Inhibition of the production of insoluble amyloid-Beta (ABeta) is a widely pursued strategy for the treatment of Alzheimer's… 
2006
2006
Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREB
ABSTRACT Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's β-amyloid precursor protein (APP… 
2006
2006
Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.
Gamma-secretase is a founding member of membrane-embedded aspartyl proteases that cleave substrates within transmembrane domains… 
2005
2005
Length and overall sequence of the PEN‐2 C‐terminal domain determines its function in the stabilization of presenilin fragments
γ‐Secretase is an aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane… 
Review
2004
Review
2004
gamma-Secretase as a target for drug intervention in Alzheimer's disease.
gamma-Secretase is a critical enzyme involved in the production of amyloid-beta (Abeta) peptide, one of the main pathological… 
2004
2004
Effects of RNA Interference-mediated Silencing of γ-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation*
Familial Alzheimer's disease mutations in the presenilin 1 gene (PSEN1) have been previously shown to potentiate caspase… 
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