Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

gamma-secretase complex

Known as: gamma-secretase complex location (APH1A, PSEN1, PSENEN, NCSTN variant), gamma-secretase complex location (APH1B, PSEN1, PSENEN, NCSTN), gamma-secretase complex location (APH1B, PSEN2, PSENEN, NCSTN) 
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Targeting the β secretase BACE1 for Alzheimer's disease therapy
The β secretase, widely known as β-site amyloid precursor protein cleaving enzyme 1 (BACE1), initiates the production of the… Expand
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Presenilin clinical mutations can affect γ‐secretase activity by different mechanisms
Mutations in human presenilin (PS) genes cause aggressive forms of familial Alzheimer's disease. Presenilins are polytopic… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited
The sequential enzymatic actions of β-APP cleaving enzyme 1 (BACE1), presenilins (PS), and other proteins of the γ-secretase… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2003
Review
2003
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
Gamma-Secretase cleaves the Amyloid Precursor Protein (APP) in its transmembrane domain, releasing the amyloid peptide Abeta… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The role of presenilin cofactors in the gamma-secretase complex.
Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD). Presenilin… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.
Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.
Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the gamma-secretase complex, and APP CTFbeta… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin*
The Alzheimer disease-associated presenilin (PS) proteins apparently provide the active site of γ-secretase, an unusual… Expand
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Neuronal Deficiency of Presenilin 1 Inhibits Amyloid Plaque Formation and Corrects Hippocampal Long-Term Potentiation But Not a Cognitive Defect of Amyloid Precursor Protein [V717I] Transgenic Mice
In the brain of Alzheimer's disease (AD) patients, neurotoxic amyloid peptides accumulate and are deposited as senile plaques. A… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE