gamma-secretase complex

Known as: gamma-secretase complex location (APH1A, PSEN1, PSENEN, NCSTN variant), gamma-secretase complex location (APH1B, PSEN1, PSENEN, NCSTN), gamma-secretase complex location (APH1B, PSEN2, PSENEN, NCSTN) 
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Mutations in human presenilin (PS) genes cause aggressive forms of familial Alzheimer's disease. Presenilins are polytopic… (More)
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Highly Cited
2005
Highly Cited
2005
Nicastrin functions as a gamma-secretase-substrate receptor.
gamma-secretase catalyzes the intramembrane cleavage of amyloid precursor protein (APP) and Notch after their extracellular… (More)
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Highly Cited
2005
Highly Cited
2005
CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
gamma-Secretase is a membrane protein complex that cleaves the beta-amyloid precursor protein (APP) within the transmembrane… (More)
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Highly Cited
2004
Highly Cited
2004
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides… (More)
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Highly Cited
2003
Highly Cited
2003
The role of presenilin cofactors in the gamma-secretase complex.
Mutations in presenilin genes account for the majority of the cases of the familial form of Alzheimer's disease (FAD). Presenilin… (More)
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Review
2003
Review
2003
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
Gamma-Secretase cleaves the Amyloid Precursor Protein (APP) in its transmembrane domain, releasing the amyloid peptide Abeta… (More)
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Highly Cited
2003
Highly Cited
2003
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo.
Epidemiologic studies demonstrate that long-term use of NSAIDs is associated with a reduced risk for the development of Alzheimer… (More)
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Highly Cited
2003
Highly Cited
2003
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
The gamma-secretase complex is an unusual multimeric protease responsible for the intramembrane cleavage of a variety of type 1… (More)
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Highly Cited
2002
Highly Cited
2002
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
The Alzheimer disease-associated presenilin (PS) proteins apparently provide the active site of gamma-secretase, an unusual… (More)
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Highly Cited
2002
Highly Cited
2002
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.
Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the gamma-secretase complex, and APP CTFbeta… (More)
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