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gamabufotalin

 
National Institutes of Health

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Bufanolides

Papers overview

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2019
2019
RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer.
Due to the non-targeted release of anti-cancer agent gamabufotalin (CS-6), conventional chemotherapy using this drug can cause… Expand
2016
2016
Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway
Gamabufotalin (CS-6), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer… Expand
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2016
2016
Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells
Deciding appropriate therapy for multiple myeloma (MM) is challenging because of the occurrence of multiple chromosomal changes… Expand
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2016
2016
Mutations to the cardiotonic steroid binding site of Na(+)/K(+)-ATPase are associated with high level of resistance to gamabufotalin in a natricine snake.
Although toads are defended by bufadienolide toxins, some snakes have evolved resistance to bufadienolides and feed heavily on… Expand
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2016
2016
Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer
Gamabufotalin (CS-6) is a major bufadienolide of Chansu, which shows desirable metabolic stability and less adverse effect in… Expand
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2015
2015
Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin Pill following oral administration to mice.
ETHNOPHARMACOLOGICAL RELEVANCE Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM… Expand
2014
2014
Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells
BackgroundGamabufotalin (CS-6), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic… Expand
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2005
2005
Arenobufagin and gamabufotalin from the venom of the Central Asian green toadBufo viridis. Introduction, structural—functional features
Two bufodienolides have been isolated in the individual form from the Central Asian green toadBufo viridis for the first time. It… Expand
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1986
1986
Activities of novel polyhydroxylated cardiotonic steroids purified from nuchal glands of the snake, Rhabdophis tigrinus
Seven novel polyhydroxylated steroids were isolated from the nucho‐dorsal glands of the snake, Rhabdophis tigrinus. Biological… Expand
1964
1964
A CHROMATOGRAPHIC STUDY OF THE BUFADIENOLIDES ISOLATED FROM THE VENOM OF THE PAROTID GLANDS OF BUFO PARACNEMIS LUTZ 1925.
Abstract A chromatographic study of the bufadienolides isolate from the venom of the parotid glands of Bufo paracnemis Lutz 1925… Expand
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