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gamabufotalin

 
National Institutes of Health

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Bufanolides

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2019
2019
RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer.
Due to the non-targeted release of anti-cancer agent gamabufotalin (CS-6), conventional chemotherapy using this drug can cause… Expand
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2016
2016
Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway
Gamabufotalin (CS-6), a main active compound isolated from Chinese medicine Chansu, has been shown to strongly inhibit cancer… Expand
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2016
2016
Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells
Deciding appropriate therapy for multiple myeloma (MM) is challenging because of the occurrence of multiple chromosomal changes… Expand
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2016
2016
Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cells.
The growth inhibitory effects of bufadienolide compounds were investigated in two intractable cancer cells, a human glioblastoma… Expand
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2016
2016
Quantitative proteomics reveals molecular mechanism of gamabufotalin and its potential inhibition on Hsp90 in lung cancer
Gamabufotalin (CS-6) is a major bufadienolide of Chansu, which shows desirable metabolic stability and less adverse effect in… Expand
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2015
2015
Pharmacokinetics and tissue distribution of five bufadienolides from the Shexiang Baoxin Pill following oral administration to mice.
ETHNOPHARMACOLOGICAL RELEVANCE Shexiang Baoxin Pill (SBP) is a well-known composite formula of traditional Chinese medicine (TCM… Expand
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2014
2014
Gamabufotalin, a bufadienolide compound from toad venom, suppresses COX-2 expression through targeting IKKβ/NF-κB signaling pathway in lung cancer cells
BackgroundGamabufotalin (CS-6), a major bufadienolide of Chansu, has been used for cancer therapy due to its desirable metabolic… Expand
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2010
2010
Preparative separation and purification of bufadienolides from Chinese traditional medicine of ChanSu using high-speed counter-current chromatography.
A preparative high-speed counter-current chromatography method for isolation and purification of bufadienolides from ChanSu was… Expand
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2005
2005
Arenobufagin and gamabufotalin from the venom of the Central Asian green toadBufo viridis. Introduction, structural—functional features
Two bufodienolides have been isolated in the individual form from the Central Asian green toadBufo viridis for the first time. It… Expand
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1999
1999
[Effect of bufalin on growth and differentiation of human skin carcinoma cells in vitro].
Bufalin, a cardiotonic steroid isolated from the Chinese toad, was previously shown to have growth inhibitory and differentiation… Expand
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