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galloflavin

 
National Institutes of Health

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Isocoumarins

Papers overview

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Review
2017
Review
2017
Non-metabolic functions of glycolytic enzymes in tumorigenesis
Cancer cells reprogram their metabolism to meet the requirement for survival and rapid growth. One hallmark of cancer metabolism… Expand
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2016
2016
Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase.
Activation of hepatic stellate cells (HSCs) is characterized by expression of extracellular matrix and loss of adipogenic… Expand
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2015
2015
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary… Expand
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2015
2015
Mild hypoxia in vivo regulates cardioprotective SUR2A: A role for Akt and LDH
High-altitude residents have lower mortality rates for ischaemic heart disease and this is ascribed to cardiac gene remodelling… Expand
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2015
2015
Phenylpropanoids and flavonoids from Phlomis kurdica as inhibitors of human lactate dehydrogenase.
Two flavonoids, jaceosidin 7-O-β-d-glucopyranosyl-(1→2)-β-d-glucopyranoside (1) and hispidulin 7-O-β-d-glucopyranosyl-(1→2)-β-d… Expand
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2015
2015
Real-time monitoring of cancer cell metabolism and effects of an anticancer agent using 2D in-cell NMR spectroscopy.
Altered metabolism is a critical part of cancer cell properties, but real-time monitoring of metabolomic profiles has been… Expand
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2013
2013
Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.
Lactate dehydrogenase A (LDH-A) binds single stranded DNA (ssDNA) and stimulates cell transcription. Binding is prevented by NADH… Expand
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2013
2013
Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1.
Activation of the myc oncogene in cancer cells upregulates lactate dehydrogenase A (LDH-A) expression, leading to a sustained… Expand
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2012
2012
Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase.
One of the most prominent alterations in cancer cells is their strict dependence on the glycolytic pathway for ATP generation… Expand
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2012
2012
Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways.
Galloflavin (GF), a recently identified lactate dehydrogenase inhibitor, hinders the proliferation of cancer cells by blocking… Expand
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