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galloflavin

National Institutes of Health

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Isocoumarins

Papers overview

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2018
2018
Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure
Graphical abstract 
Review
2018
Review
2018
Reciprocal Regulation of Metabolic Reprogramming and Epigenetic Modifications in Cancer
Cancer cells reprogram their metabolism to meet their demands for survival and proliferation. The metabolic plasticity of tumor… Expand
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Review
2017
Review
2017
Non-metabolic functions of glycolytic enzymes in tumorigenesis
Cancer cells reprogram their metabolism to meet the requirement for survival and rapid growth. One hallmark of cancer metabolism… Expand
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2017
2017
Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells
&NA; The inflammatory microenvironment is an essential component of neoplastic lesions and can significantly impact on tumor… Expand
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2015
2015
Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells
High rates of aerobic glycolysis represent a key mechanism by which endometrial cancer cells consume glucose as its primary… Expand
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2015
2015
Real-time monitoring of cancer cell metabolism and effects of an anticancer agent using 2D in-cell NMR spectroscopy.
Altered metabolism is a critical part of cancer cell properties, but real-time monitoring of metabolomic profiles has been… Expand
2013
2013
Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1
Activation of the myc oncogene in cancer cells upregulates lactate dehydrogenase A (LDH-A) expression, leading to a sustained… Expand
2013
2013
Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.
Lactate dehydrogenase A (LDH-A) binds single stranded DNA (ssDNA) and stimulates cell transcription. Binding is prevented by NADH… Expand
Highly Cited
2012
Highly Cited
2012
Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways.
Galloflavin (GF), a recently identified lactate dehydrogenase inhibitor, hinders the proliferation of cancer cells by blocking… Expand
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Highly Cited
2012
Highly Cited
2012
Galloflavin (CAS 568‐80‐9): A Novel Inhibitor of Lactate Dehydrogenase
One of the most prominent alterations in cancer cells is their strict dependence on the glycolytic pathway for ATP generation… Expand
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