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furafylline
Known as:
1,8-dimethyl-3-(2'-furfuryl)-1H-purine-2,6-dione
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Theophylline
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes.
B. Piver
,
M. Fer
,
+4 authors
D. Lucas
Biochemical pharmacology
2004
Corpus ID: 38583385
Highly Cited
2003
Highly Cited
2003
High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.
S. A. Testino
,
G. Patonay
Journal of pharmaceutical and biomedical analysis
2003
Corpus ID: 9102746
Highly Cited
2002
Highly Cited
2002
Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity.
L. Zou
,
M. Harkey
,
G. Henderson
Life sciences
2002
Corpus ID: 23942793
Highly Cited
1999
Highly Cited
1999
Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug…
A. Li
,
C. Lu
,
+4 authors
P. Silber
Chemico-biological interactions
1999
Corpus ID: 23059407
Highly Cited
1999
Highly Cited
1999
Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity.
G. Henderson
,
M. Harkey
,
M. Gershwin
,
R. Hackman
,
J. Stern
,
D. Stresser
Life sciences
1999
Corpus ID: 12163154
Highly Cited
1996
Highly Cited
1996
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine, and norantipyrine formation
G. Engel
,
U. Hofmann
,
Hugo Heidemann
,
J. Cosme
,
M. Eichelbaum
Clinical pharmacology and therapeutics
1996
Corpus ID: 23254828
Highly Cited
1995
Highly Cited
1995
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
D. Newton
,
R. Wang
,
A. Y. Lu
Drug metabolism and disposition: the biological…
1995
Corpus ID: 7124871
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s…
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Highly Cited
1994
Highly Cited
1994
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.
M. Burke
,
S. Thompson
,
R. Weaver
,
C. Wolf
,
R. Mayer
Biochemical pharmacology
1994
Corpus ID: 24744358
Highly Cited
1993
Highly Cited
1993
Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline.
K. Kunze
,
W. Trager
Chemical research in toxicology
1993
Corpus ID: 46451821
Biotransformation reactions catalyzed by human cytochrome P450 1A2 (P450 1A2) appear to play a significant role in both the…
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Highly Cited
1990
Highly Cited
1990
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.
D. Sesardic
,
A. Boobis
,
+4 authors
D. Davies
British journal of clinical pharmacology
1990
Corpus ID: 21961448
1. Furafylline (1,8-dimethyl-3-(2'-furfuryl)methylxanthine) is a methylxanthine derivative that was introduced as a long-acting…
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