furafylline

We evaluated the effects of 25 purified components of commonly used herbal products on the catalytic activity of cDNA-expressed… (More)

AIMS Chemical inhibitors of cytochrome P450 (CYP) are a useful tool in defining the role of individual CYPs involved in drug… (More)

Cytochrome P450 chemical inhibitors are widely used to define the role of individual cytochrome P450 isozyme(s) in a metabolism… (More)

Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… (More)

The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes for measuring the cytochrome P450… (More)

1. Furafylline inhibition of 1A2-related activity in human liver microsomal systems was characterized. This inhibition was time… (More)

The contribution of CYP1A2 to the metabolism of the dietary heterocyclic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine… (More)

Biotransformation reactions catalyzed by human cytochrome P450 1A2 (P450 1A2) appear to play a significant role in both the… (More)

1. Furafylline (1,8-dimethyl-3-(2'-furfuryl)methylxanthine) is a methylxanthine derivative that was introduced as a long-acting… (More)

The pharmacokinetics and tolerance of repeated oral doses of furafylline were investigated in normal volunteers. In accord with… (More)