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furafylline

Known as: 1,8-dimethyl-3-(2'-furfuryl)-1H-purine-2,6-dione 
National Institutes of Health

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2 relations

Broader (1)

Theophylline
analogs & derivatives

Papers overview

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Highly Cited
2004
Highly Cited
2004
Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes.
Highly Cited
2003
Highly Cited
2003
High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.
Highly Cited
2002
Highly Cited
2002
Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity.
Highly Cited
1999
Highly Cited
1999
Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug…
Highly Cited
1999
Highly Cited
1999
Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity.
Highly Cited
1996
Highly Cited
1996
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4‐hydroxyantipyrine, 3‐hydroxymethylantipyrine, and norantipyrine formation
Highly Cited
1995
Highly Cited
1995
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… 
Highly Cited
1994
Highly Cited
1994
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver.
Highly Cited
1993
Highly Cited
1993
Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline.
Biotransformation reactions catalyzed by human cytochrome P450 1A2 (P450 1A2) appear to play a significant role in both the… 
Highly Cited
1990
Highly Cited
1990
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.
1. Furafylline (1,8-dimethyl-3-(2'-furfuryl)methylxanthine) is a methylxanthine derivative that was introduced as a long-acting… 
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