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furafylline

Known as: 1,8-dimethyl-3-(2'-furfuryl)-1H-purine-2,6-dione 
 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The cytochrome P450 (P450) superfamily plays an important role in the metabolism of drug compounds, and it is therefore highly… Expand
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Highly Cited
1999
Highly Cited
1999
Cryopreserved human hepatocytes were extensively characterized in our laboratory. The post-thaw viability, measured via dye… Expand
Highly Cited
1998
Highly Cited
1998
AIMS Chemical inhibitors of cytochrome P450 (CYP) are a useful tool in defining the role of individual CYPs involved in drug… Expand
Highly Cited
1997
Highly Cited
1997
As domestic animals such as cat, horse, and dog increasingly become the clinical targets for drug discovery programs, the need to… Expand
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Highly Cited
1996
Highly Cited
1996
Antipyrine has been widely used as a probe drug for human oxidative drug metabolism. To evaluate the role of antipyrine as a… Expand
Highly Cited
1996
Highly Cited
1996
Cytochrome P450 chemical inhibitors are widely used to define the role of individual cytochrome P450 isozyme(s) in a metabolism… Expand
Highly Cited
1995
Highly Cited
1995
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… Expand
Highly Cited
1994
Highly Cited
1994
The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes for measuring the cytochrome P450… Expand
Highly Cited
1993
Highly Cited
1993
Biotransformation reactions catalyzed by human cytochrome P450 1A2 (P450 1A2) appear to play a significant role in both the… Expand
Highly Cited
1990
Highly Cited
1990
1. Furafylline (1,8-dimethyl-3-(2'-furfuryl)methylxanthine) is a methylxanthine derivative that was introduced as a long-acting… Expand