furafylline

The cytochrome P450 (P450) superfamily plays an important role in the metabolism of drug compounds, and it is therefore highly… Expand

Cryopreserved human hepatocytes were extensively characterized in our laboratory. The post-thaw viability, measured via dye… Expand

AIMS Chemical inhibitors of cytochrome P450 (CYP) are a useful tool in defining the role of individual CYPs involved in drug… Expand

As domestic animals such as cat, horse, and dog increasingly become the clinical targets for drug discovery programs, the need to… Expand

Antipyrine has been widely used as a probe drug for human oxidative drug metabolism. To evaluate the role of antipyrine as a… Expand

Cytochrome P450 chemical inhibitors are widely used to define the role of individual cytochrome P450 isozyme(s) in a metabolism… Expand

Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s… Expand

The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes for measuring the cytochrome P450… Expand

Biotransformation reactions catalyzed by human cytochrome P450 1A2 (P450 1A2) appear to play a significant role in both the… Expand

1. Furafylline (1,8-dimethyl-3-(2'-furfuryl)methylxanthine) is a methylxanthine derivative that was introduced as a long-acting… Expand