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The progression and exacerbations of chronic obstructive pulmonary disease (COPD) are intimately associated with tobacco smoke… Expand Increased oxidative stress occurs in the lungs and systemically in COPD, which plays a role in many of the pathogenic mechanisms… Expand Cigarette/tobacco smoke/biomass fuel-induced oxidative and aldehyde/carbonyl stress are intimately associated with the… Expand BACKGROUND
Peroxynitrite (PN) formed by the reaction of nitric oxide and superoxide is a powerful oxidant/nitrosant. Nitrative… Expand Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox… Expand Fudosteine is a novel mucoactive agent, although little is known about how fudosteine decreases mucin production. The present… Expand A 96-well protein precipitation, liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and fully… Expand A rapid and selective liquid chromatographic/tandem mass spectrometric method for determination of fosfomycin was developed and… Expand We evaluated the effect of a mucoactive agent (-)-(R)-2-amino-3-(3-hydroxypropylthio) propionic acid (fudosteine), on airway… Expand We examined the effect of fudosteine ((—)‐(R)‐2‐amino‐3‐(3‐hydroxypropylthio)propionic acid) on the mucociliary transport (MCT… Expand