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fontolizumab

Known as: HUZAF, Immunoglobulin G1, Anti-(Human Interferon Gamma) (Human-Mouse Monoclonal Huzaf Gamma-1-Chain), Disulfide with Human-Mouse Monoclonal Huzaf Light Chain, Dimer 
A humanized monoclonal antibody directed against interferon-gamma (IFN-g) with immunomodulatory activity. Fontolizumab binds to and prevents the… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Antibodies, Monoclonal, Humanized
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Not all monoclonals are created equal - lessons from failed drug trials in Crohn's disease.
  • A. Kaser
  • Best practice & research. Clinical…
  • 2014
  • Corpus ID: 3277888
Review
2013
Review
2013
[Pharmacology of biologic medications].
Two major types of inflammatory bowel diseases (IBD) are Crohn's disease (CD) and ulcerative colitis (UC). Insights into their… 
2011
2011
TH1/TH17 profiles in crohn's disease: a cross sectional single centre study in postoperative crohn's disease
Introduction Th1 and Th17 pathways are implicated in Crohn's disease (CD). In operative resection samples healthy ileum shows… 
2007
2007
Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's diseaseHommes DW, Mikhajlova TL, Stoinov S, et al (Academic…
2007
2007
A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon γ antibody, in patients with moderate to…
2006
2006
Intérêt de l’antiinterféron gamma (fontolizumab) dans la maladie de Crohn (MC) modérée à sévère
alors appari6s avec des sujets t6moins pour des crit~res d'~ge, de sexe et de dur6e de suivi. Les patients qui avaient pr6sent6… 
Review
2004
Review
2004
How future tumor necrosis factor antagonists and other compounds will meet the remaining challenges in Crohn's disease.
The chimeric monoclonal antibody to tumor necrosis factor (TNF), infliximab, is an effective therapy for Crohn's disease. However… 
2004
2004
Fontolizumab (Huzaf), a humanized anti-IFN-gamma antibody, has clinical activity and excellent tolerability in moderate to severe Crohn’s disease
2004
2004
Three-dimensional structures of a humanized anti-IFN-gamma Fab (HuZAF) in two crystal forms.
Three-dimensional structures were determined for two crystal forms (orthorhombic P2(1)2(1)2(1) and monoclinic C2) of the Fab from… 
2003
2003
HuZAF, a humanized anti-IFN-γ antibody, inhibits chemokine production by activated T cells and intestinal epithelial cells and blocks chemotaxis of activated CXCR3+lymphocytes
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