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fontolizumab

Known as: HUZAF, Immunoglobulin G1, Anti-(Human Interferon Gamma) (Human-Mouse Monoclonal Huzaf Gamma-1-Chain), Disulfide with Human-Mouse Monoclonal Huzaf Light Chain, Dimer 
A humanized monoclonal antibody directed against interferon-gamma (IFN-g) with immunomodulatory activity. Fontolizumab binds to and prevents the… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The past three decades have witnessed remarkable advances in our ability to target specific elements of the immune and… Expand
Review
2014
Review
2014
  • A. Kaser
  • Best practice & research. Clinical…
  • 2014
  • Corpus ID: 3277888
The recent success of the anti-integrin antibody Vedolizumab can barely conceal the fact that the biologics armamentarium in… Expand
Highly Cited
2010
Highly Cited
2010
Background: The safety and efficacy of fontolizumab, a humanized anti‐interferon gamma antibody, was investigated in patients… Expand
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2008
2008
Therapeutic antibodies against tumor necrosis factor (TNF) (infliximab) and IFNgamma (fontolizumab) have been developed to treat… Expand
Highly Cited
2006
Highly Cited
2006
Introduction: Interferon γ is a potent proinflammatory cytokine implicated in the inflammation of Crohn’s disease (CD). We… Expand
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Highly Cited
2006
Highly Cited
2006
Introduction: This study was designed to evaluate the safety of fontolizumab, a humanised anti-interferon γ antibody, in patients… Expand
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Review
2006
Review
2006
Early experience of fontolizumab, a humanised anti-interferon γ antibody, in active Crohn’s disease has shown that the drug… Expand
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Review
2005
Review
2005
  • F. Dumont
  • Current opinion in investigational drugs
  • 2005
  • Corpus ID: 42324864
Protein Design Labs is developing fontolizumab, a humanized anti-interferon gamma monoclonal antibody, for the potential… Expand
Review
2005
Review
2005
  • S. Travis
  • Current gastroenterology reports
  • 2005
  • Corpus ID: 39353292
Advances (from 2004 to 2006) in the use of conventional agents include the molecular mechanisms of action, which have… Expand
Review
2004
Review
2004
  • W. Sandborn
  • Reviews in gastroenterological disorders
  • 2004
  • Corpus ID: 25358869
The chimeric monoclonal antibody to tumor necrosis factor (TNF), infliximab, is an effective therapy for Crohn's disease. However… Expand