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fontolizumab

Known as: HUZAF, Immunoglobulin G1, Anti-(Human Interferon Gamma) (Human-Mouse Monoclonal Huzaf Gamma-1-Chain), Disulfide with Human-Mouse Monoclonal Huzaf Light Chain, Dimer 
A humanized monoclonal antibody directed against interferon-gamma (IFN-g) with immunomodulatory activity. Fontolizumab binds to and prevents the… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Antibodies, Monoclonal, Humanized
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn’s disease and…
The past three decades have witnessed remarkable advances in our ability to target specific elements of the immune and… Expand
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Highly Cited
2010
Highly Cited
2010
Fontolizumab in moderate to severe Crohn's disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study.
BACKGROUND The safety and efficacy of fontolizumab, a humanized anti-interferon gamma antibody, was investigated in patients with… Expand
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2008
2008
Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome.
Therapeutic antibodies against tumor necrosis factor (TNF) (infliximab) and IFNgamma (fontolizumab) have been developed to treat… Expand
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Highly Cited
2006
Highly Cited
2006
Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease.
INTRODUCTION Interferon gamma is a potent proinflammatory cytokine implicated in the inflammation of Crohn's disease (CD). We… Expand
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2006
2006
Fontolizumab, a humanised anti-interferon γ antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Commentary
Introduction: Interferon y is a potent proinflammatory cytokine implicated in the inflammation of Crohn's disease (CD). We… Expand
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Highly Cited
2005
Highly Cited
2005
A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to…
INTRODUCTION This study was designed to evaluate the safety of fontolizumab, a humanised anti-interferon gamma antibody, in… Expand
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Review
2005
Review
2005
Fontolizumab Protein Design Labs.
Protein Design Labs is developing fontolizumab, a humanized anti-interferon gamma monoclonal antibody, for the potential… Expand
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Review
2005
Review
2005
Interfering with interferons in inflammatory bowel disease.
Early experience of fontolizumab, a humanised anti‐interferon γ antibody, in active Crohn's disease has shown that the drug… Expand
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Review
2005
Review
2005
Advances in therapeutic approaches to ulcerative colitis and crohn’s disease
Advances (from 2004 to 2006) in the use of conventional agents include the molecular mechanisms of action, which have… Expand
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2004
2004
Fontolizumab (Huzaf), a humanized anti-IFN-gamma antibody, has clinical activity and excellent tolerability in moderate to severe Crohn’s disease
 
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