fomepizole

Known as: 4-Methylpyrazol, 1H-Pyrazole, 4-methyl-, 4-methylpyrazole 
A pyrazole with competitive alcohol dehydrogenase inhibitor activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by alcohol… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2018
0204019702018

Papers overview

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Highly Cited
2006
Highly Cited
2006
Patients with alcoholic liver disease frequently exhibit iron overload in association with increased hepatic fibrosis. Even… (More)
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Highly Cited
2002
Highly Cited
2002
Alcoholic fatty liver is the earliest and most common response of the liver to alcohol and may be a precursor of more severe… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Methanol poisoning may result in metabolic acidosis, blindness, and death. The inhibition of alcohol dehydrogenase is… (More)
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Highly Cited
2001
Highly Cited
2001
Ethanol metabolism causes oxidative stress and lipid peroxidation not only in liver but also in extra-hepatic tissues. Ethanol… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. The standard treatment is… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND & AIMS Ethanol causes oxidative stress in the hepatic mitochondria of experimental animals and mitochondrial DNA… (More)
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Highly Cited
1998
Highly Cited
1998
An enzyme isolated from rat liver cytosol (native molecular mass 78. 3 kDa; polypeptide molecular mass 42.5 kDa) is capable of… (More)
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Highly Cited
1997
Highly Cited
1997
Chronic ethanol ingestion leads to an enhanced risk of upper gastrointestinal tract cancer. Although many hypotheses for the… (More)
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Highly Cited
1997
Highly Cited
1997
Nine organic solvents and 47 commonly used P450 substrates and inhibitors were examined for their effects on coumarin 7… (More)
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