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National Institutes of Health
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Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.
D. V. van Aalten
The Biochemical journal
Corpus ID: 9201933
PDK1 (3-phosphoinositide-dependent protein kinase-1) is a member of the AGC (cAMP-dependent, cGMP-dependent, protein kinase C…
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia…
Corpus ID: 2265074
Interactions between the checkpoint abrogator UCN-01 and several pharmacological inhibitors of the mitogen-activated protein…
UCN-01 Kyowa Hakko Kogyo Co.
Current opinion in investigational drugs
Corpus ID: 41627330
Kyowa Hakko Kogyo is developing UCN-01, a selective but non-specific inhibitor of kinases with good activity against protein…
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