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fidarestat

Known as: (2S,4S)-6-fluoro-2',5'-dioxospiro(chroman-4,4'-imidazolidine)-2-carboxamide, Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S-cis)- 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Imidazolidines

Narrower (1)

SNK 860

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease
2012
2012
Amelioration of Acute Kidney Injury in Lipopolysaccharide-Induced Systemic Inflammatory Response Syndrome by an Aldose Reductase Inhibitor, Fidarestat
Background Systemic inflammatory response syndrome is a fatal disease because of multiple organ failure. Acute kidney injury is a… 
2011
2011
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages.
Highly Cited
2006
Highly Cited
2006
Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells.
2005
2005
Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.
Structure of the Leu300Pro mutant of human aldose reductase (ALR2) in complex with the inhibitor fidarestat is determined… 
2004
2004
Probing the ultra-high resolution structure of aldose reductase with molecular modelling and noncovalent mass spectrometry.
2004
2004
High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type…
Structure determinations of human aldose reductase holoenzyme in complex with the 2S4R-,2R4S- and 2R4R-isomers of the potent… 
Highly Cited
2003
Highly Cited
2003
Differential influence of increased polyol pathway on protein kinase C expressions between endoneurial and epineurial tissues in diabetic mice
To explore the relationship between polyol pathway and protein kinase C (PKC), we examined PKC activities and expressions of PKC… 
Highly Cited
2002
Highly Cited
2002
Sorbitol dehydrogenase overexpression potentiates glucose toxicity to cultured retinal pericytes.
2000
2000
Inhibitory effects of fidarestat on aldose reductase and aldehyde reductase activity evaluated by a new method using HPLC with post-column spectrophotometric detection.
A new method to assay the activity of aldose reductase (AR) and aldehyde reductase (AHR) by high-performance liquid… 
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