febuxostat

Known as: 2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid, Febuxostatum, 2-(3-Cyano-4-(2-methylpropoxy)phenyl)-4-methylthiazole-5-carboxylic Acid 
An orally available, non-purine inhibitor of xanthine oxidase with uric acid lowering activity. Upon oral administration, febuxostat selectively and… (More)
National Institutes of Health

Papers overview

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2014
2014
Atherosclerosis is a chronic inflammatory disease due to lipid deposition in the arterial wall. Multiple mechanisms participate… (More)
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2011
Highly Cited
2011
BACKGROUND The association between hyperuricemia, gout, and impaired renal function has long been recognized. Recent data provide… (More)
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Highly Cited
2010
Highly Cited
2010
INTRODUCTION The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE To determine longterm urate-lowering efficacy and clinical benefits and safety of therapy with febuxostat or… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVE To compare the urate-lowering efficacy and safety of febuxostat, allopurinol, and placebo in a large group of subjects… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES This 5-yr study assessed urate-lowering and clinical efficacy and safety of long-term febuxostat therapy in subjects… (More)
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Highly Cited
2008
Highly Cited
2008
Increased fructose consumption is associated with hyperuricemia, metabolic syndrome, and renal damage. This study evaluated… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, is a potential alternative to allopurinol for… (More)
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Highly Cited
2005
Highly Cited
2005
The purine analogue, allopurinol, has been in clinical use for more than 30 years as an inhibitor of xanthine oxidase (XO) in the… (More)
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE Gout affects approximately 1-2% of the American population. Current options for treating hyperuricemia in chronic gout… (More)
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