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fast axonal transport

 
National Institutes of Health

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1 relation

Broader (1)

neuronal transport

Papers overview

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Highly Cited
2013
Highly Cited
2013
Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport
Fast axonal transport (FAT) requires consistent energy over long distances to fuel the molecular motors that transport vesicles… Expand
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Review
2013
Review
2013
Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system
Alzheimer's disease (AD) is characterized by progressive, age-dependent degeneration of neurons in the central nervous system. A… Expand
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Highly Cited
2012
Highly Cited
2012
Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport
Alzheimer's disease (AD) and other tauopathies are characterized by fibrillar inclusions composed of the microtubule-associated… Expand
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Highly Cited
2011
Highly Cited
2011
Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases
Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein) represent pathological hallmarks of… Expand
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Highly Cited
2009
Highly Cited
2009
Pathogenic Huntingtin Inhibits Fast Axonal Transport by Activating JNK3 and Phosphorylating Kinesin
Selected vulnerability of neurons in Huntington's disease suggests that alterations occur in a cellular process that is… Expand
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Highly Cited
2009
Highly Cited
2009
The amino terminus of tau inhibits kinesin-dependent axonal transport: implications for filament toxicity.
The neuropathology of Alzheimer's disease (AD) and other tauopathies is characterized by filamentous deposits of the microtubule… Expand
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Highly Cited
2009
Highly Cited
2009
Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta
The pathological mechanism by which Aβ causes neuronal dysfunction and death remains largely unknown. Deficiencies in fast axonal… Expand
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Highly Cited
2007
Highly Cited
2007
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu… Expand
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Highly Cited
2007
Highly Cited
2007
Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing Familial Alzheimer's Disease-Linked Mutant Presenilin 1
Presenilins (PS) play a central role in γ-secretase-mediated processing of β-amyloid precursor protein (APP) and numerous type I… Expand
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Highly Cited
2006
Highly Cited
2006
JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport
Expansion of the polyglutamine (polyQ) stretch in the androgen receptor (AR) protein leads to spinal and bulbar muscular atrophy… Expand
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