farnesyltranstransferase

Known as: Farnesyltranstransferase [Chemical/Ingredient], Farnesyl Diphosphate-Geranylgeranyl Diphosphate Synthase, Geranylgeranyl Pyrophosphatase 
An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the production of a truncated prelamin A, called progerin, which is… (More)
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Highly Cited
2004
Highly Cited
2004
The tomato (Lycopersicon esculentum) mutant def-1, which is deficient in induced jasmonic acid (JA) accumulation upon wounding or… (More)
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Highly Cited
2002
Highly Cited
2002
High-throughput and virtual screening are widely used to discover novel leads for drug design. On examination, many screening… (More)
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Highly Cited
2002
Highly Cited
2002
Phytoene synthase from the bacterium Erwinia uredovora (crtB) has been overexpressed in tomato (Lycopersicon esculentum Mill. cv… (More)
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Highly Cited
1999
Highly Cited
1999
Nitrogen-containing bisphosphonates were shown to cause macrophage apoptosis by inhibiting enzymes in the biosynthetic pathway… (More)
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Highly Cited
1998
Highly Cited
1998
Bisphosphonates are currently the most important class of antiresorptive drugs used for the treatment of metabolic bone diseases… (More)
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Highly Cited
1997
Highly Cited
1997
The association of mutant forms of Ras protein with a variety of human cancers has stimulated intense interest in therapies based… (More)
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Highly Cited
1995
Highly Cited
1995
For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction… (More)
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Highly Cited
1990
Highly Cited
1990
The most important function of carotenoid pigments, especially beta-carotene in higher plants, is to protect organisms against… (More)
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