falintolol

Known as: O-(3-(tert-butylamino)-2-hydroxypropyl)cyclopropyl methyl ketone oxime

National Institutes of Health

Papers overview

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1998

1998

Synthesis of new delta 2-isoxazoline derivatives and their pharmacological characterization as beta-adrenergic receptor antagonists.

P. Conti, Clelia Dallanoce, Marco De Amici, Carlo De Micheli, Karl-Norbert Klotz
Bioorganic & medicinal chemistry
1998

A series of delta 2-isoxazoline derivatives structurally related to Broxaterol 1 and Falintolol 3 has been prepared and evaluated… (More)

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1989

1989

Pharmacokinetics of falintolol II. Absorption, distribution and elimination from tissues and organs following ocular administration and intravenous injection of falintolol in albino rabbits.

G. Andermann, Pascal Guggenbuhl, Georges de Burlet, Jacques Himber
Methods and findings in experimental and clinical…
1989

The absorption, distribution and elimination of falintolol maleate was studied in various ocular and extraocular tissues and… (More)

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1987

1987

Effects of topically applied falintolol: a new beta-adrenergic antagonist for treatment of glaucoma.

Jacques Himber, Verney L. Sallee, G. Andermann, M. Bouzoubaa, Guy J. Leclerc, Lorenzo De Santis
Journal of ocular pharmacology
1987

Changes in intraocular pressure (IOP) following topical administration of falintolol (0.5%-0.25%), a new beta-blocking agent… (More)

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1987

1987

Determination of falintolol, a new aliphatic beta-adrenergic antagonist, in whole blood by gas chromatography with electron-capture detection: geometric isomers resolution.

Jacques Himber, G. Andermann, M. Bouzoubaa, Guy J. Leclerc
Journal of chromatographic science
1987

Falintolol oxalate, a new beta-adrenergic antagonist, is characterized by the presence of an oxime function and exists in a… (More)

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1985

1985

In vitro potential measurement, anaesthetic and antimicrobial effects as indicators of beta-blocker toxicity of the cornea.

Jacques Himber, G. Andermann, Matthew Erhart, Guy J. Leclerc, M. Bouzoubaa
Methods and findings in experimental and clinical…
1985

Three tests were utilized to determine and compare the toxicity of timolol, propranolol and two new aliphatic and alicyclic oxime… (More)

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1985

1985

New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.

M. Bouzoubaa, Guy J. Leclerc, Suman Rakhit, G. Andermann
Journal of medicinal chemistry
1985

The synthesis of R-(+) and S-(-) isomers of O-[3-tert-butylamino)-2-hydroxypropyl] cyclopropyl methyl ketone oxime (falintolol… (More)

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