ezlopitant

Known as: (2S,3S)-2-(Diphenylmethyl)-3-((5-isopropyl-2-methoxybenzyl)amino)quinuclidine, (2S,3S,4S)-2-diphenylmethyl-3-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane, (2S,3S)-2-(Diphenylmethyl)-3-((5-isopropyl-2-methoxy- benzyl)amino)quinuclidine 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1999-2010
012319992010

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
BACKGROUND The current obesity epidemic is thought to be partly driven by over-consumption of sugar-sweetened diets and soft… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2007
2007
The excretion, biotransformation, and pharmacokinetics of ezlopitant [(2-benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl)-(5-isopropyl-2… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The effects of microsomal concentration on the inhibitory potencies of four compounds--fluoxetine, quinidine, imipramine, and… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
2002
2002
The anti-emetic effects of a novel tachykinin NK(1) receptor antagonist, ezlopitant ((2S,3S-cis)-2-diphenylmethyl)- N-[(2-methoxy… (More)
Is this relevant?
2001
2001
  • R Scott Obach
  • Drug metabolism and disposition: the biological…
  • 2001
Ezlopitant is metabolized by cytochrome P450 primarily to two metabolites: a benzyl alcohol and a corresponding alkene. The… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • table 4
Is this relevant?
2001
2001
  • R Scott Obach
  • Drug metabolism and disposition: the biological…
  • 2001
Experiments were conducted to characterize the metabolism of ezlopitant alkene (CJ-12,458), an active metabolite of ezlopitant… (More)
  • figure 1
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
2000
2000
  • R Scott Obach
  • Drug metabolism and disposition: the biological…
  • 2000
The enzyme kinetics of the metabolism of ezlopitant in liver microsomes from various species have been determined. The rank order… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
2000
2000
A simple, but highly sensitive and specific, assay was developed for the quantitative determination of ezlopitant and its two… (More)
Is this relevant?
2000
2000
A method for the analysis of the substance P antagonist ezlopitant and two active metabolites in serum using solid-phase… (More)
Is this relevant?
1999
1999
The pharmacokinetics of ezlopitant were determined in the rat, gerbil, guinea pig, ferret, dog and monkey after intravenous and… (More)
Is this relevant?