ezetimibe

Known as: Ezetimiba, (1-(4-fluorophenyl)-(3R)-(3-(4-fluorophenyl)-(3S)-hydroxypropyl)-(4S)-(4-hydroxyphenyl)-2-azetidinone), Ezetimibe [Chemical/Ingredient] 
An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
IMPORTANCE In phase 2 studies, evolocumab, a fully human monoclonal antibody to PCSK9, reduced LDL-C levels in patients receiving… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Inhibition of proprotein convertase subtilisin/kexin type 9 serine protease (PCSK9) resulted in large reductions of… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Treatment added to statin monotherapy to further modify the lipid profile may include combination therapy to either… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND By inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, statins not only reduce cholesterol biosynthesis but… (More)
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Highly Cited
2008
Highly Cited
2008
Niemann-Pick C1-like 1 (NPC1L1) is a polytopic transmembrane protein that plays a critical role in cholesterol absorption… (More)
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Highly Cited
2007
Highly Cited
2007
Niemann-Pick C1-like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a… (More)
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Highly Cited
2004
Highly Cited
2004
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Ezetimibe has been shown to inhibit cholesterol absorption in animal models, but studies on cholesterol absorption in… (More)
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Highly Cited
2002
Highly Cited
2002
Ezetimibe is a lipid-lowering drug that inhibits the intestinal absorption of dietary and biliary cholesterol by blocking passage… (More)
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