ethyl 2-cyano-2-(hydroxyimino)acetate
National Institutes of Health
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A methodology for the solid-phase synthesis of biaryl bicyclic peptides containing a Phe-Phe, a Phe-Tyr or a Tyr-Tyr motif has…
Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY) mediated Lossen rearrangement and its application for the…
A diisopropylcarbodiimide/Oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) coupling cocktail was successfully incorporated into the…
OxymaPure (ethyl 2-cyano-2-(hydroxyimino)acetate) was tested as an additive for use in the carbodiimide (DIC) approach for the…
The presence of low pKa N‐hydroxylamines is beneficial in peptide chemistry as they reduce some base‐mediated side reactions…
A new family of sulfonate ester-type coupling reagents is described which differs in its leaving group. The sulfonate ester…
COMU is a third generation of uronium‐type coupling reagent based on ethyl 2‐cyano‐2‐(hydroxyimino)acetate (Oxyma) as well as a…
Recent studies described the great impact of a non-benzotriazolic family of coupling reagents based on ethyl 2-cyano-2…
We describe a new family of uronium-type coupling reagents that differ in their iminium moieties and leaving groups. The presence…
Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] has been tested as an additive for use in the carbodiimide approach for formation…