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ethyl 2-cyano-2-(hydroxyimino)acetate

 
National Institutes of Health

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AcetatesOximes

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2014
2014
Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate-mediated Lossen rearrangement: single-pot racemization-free synthesis of hydroxamic acids and ureas from carboxylic acids.
Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY) mediated Lossen rearrangement and its application for the… Expand
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2014
2014
Oxyma-B, an excellent racemization suppressor for peptide synthesis.
Peptide-bond formation is a key process in the synthesis of peptide oligomers. Among the many coupling techniques reported… Expand
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2014
2014
Efficient microwave-assisted one shot synthesis of peptaibols using inexpensive coupling reagents.
A diisopropylcarbodiimide/Oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) coupling cocktail was successfully incorporated into the… Expand
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2013
2013
OxymaPure/DIC: An Efficient Reagent for the Synthesis of a Novel Series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] Benzoyl Amino Acid Ester Derivatives
OxymaPure (ethyl 2-cyano-2-(hydroxyimino)acetate) was tested as an additive for use in the carbodiimide (DIC) approach for the… Expand
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2012
2012
Use of Oxyma as pH modulatory agent to be used in the prevention of base-driven side reactions and its effect on 2-chlorotrityl chloride resin.
The presence of low pKa N-hydroxylamines is beneficial in peptide chemistry as they reduce some base-mediated side reactions… Expand
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2010
2010
COMU: a third generation of uronium-type coupling reagents.
COMU is a third generation of uronium-type coupling reagent based on ethyl 2-cyano-2-(hydroxyimino)acetate (Oxyma) as well as a… Expand
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2010
2010
Sulfonate esters of 1-hydroxypyridin-2(1H)-one and ethyl 2-cyano-2-(hydroxyimino)acetate (oxyma) as effective peptide coupling reagents to replace 1-hydroxybenzotriazole and 1-hydroxy-7…
A new family of sulfonate ester-type coupling reagents is described which differs in its leaving group. The sulfonate ester… Expand
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2010
2010
PyOxP and PyOxB: the Oxyma-based novel family of phosphonium salts.
Recent studies described the great impact of a non-benzotriazolic family of coupling reagents based on ethyl 2-cyano-2… Expand
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Highly Cited
2009
Highly Cited
2009
Oxyma: an efficient additive for peptide synthesis to replace the benzotriazole-based HOBt and HOAt with a lower risk of explosion.
Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] has been tested as an additive for use in the carbodiimide approach for formation… Expand
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Highly Cited
2009
Highly Cited
2009
COMU: a safer and more effective replacement for benzotriazole-based uronium coupling reagents.
We describe a new family of uronium-type coupling reagents that differ in their iminium moieties and leaving groups. The presence… Expand
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