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ethyl 2-cyano-2-(hydroxyimino)acetate

 
National Institutes of Health

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AcetatesOximes

Papers overview

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2014
2014
Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate-mediated Lossen rearrangement: single-pot racemization-free synthesis of hydroxamic acids and ureas from carboxylic acids.
Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)acetate (4-NBsOXY) mediated Lossen rearrangement and its application for the… Expand
2014
2014
Efficient microwave-assisted one shot synthesis of peptaibols using inexpensive coupling reagents.
A diisopropylcarbodiimide/Oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) coupling cocktail was successfully incorporated into the… Expand
2013
2013
OxymaPure/DIC: An Efficient Reagent for the Synthesis of a Novel Series of 4-[2-(2-Acetylaminophenyl)-2-oxo-acetylamino] Benzoyl Amino Acid Ester Derivatives
OxymaPure (ethyl 2-cyano-2-(hydroxyimino)acetate) was tested as an additive for use in the carbodiimide (DIC) approach for the… Expand
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2012
2012
Use of Oxyma as pH modulatory agent to be used in the prevention of base‐driven side reactions and its effect on 2‐chlorotrityl chloride resin
The presence of low pKa N‐hydroxylamines is beneficial in peptide chemistry as they reduce some base‐mediated side reactions… Expand
2010
2010
Sulfonate esters of 1-hydroxypyridin-2(1H)-one and ethyl 2-cyano-2-(hydroxyimino)acetate (oxyma) as effective peptide coupling reagents to replace 1-hydroxybenzotriazole and 1-hydroxy-7…
A new family of sulfonate ester-type coupling reagents is described which differs in its leaving group. The sulfonate ester… Expand
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Highly Cited
2010
Highly Cited
2010
COMU: A third generation of uronium‐type coupling reagents
COMU is a third generation of uronium‐type coupling reagent based on ethyl 2‐cyano‐2‐(hydroxyimino)acetate (Oxyma) as well as a… Expand
2010
2010
PyOxP and PyOxB: the Oxyma-based novel family of phosphonium salts.
Recent studies described the great impact of a non-benzotriazolic family of coupling reagents based on ethyl 2-cyano-2… Expand
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2010
2010
Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis
A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide… Expand
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Highly Cited
2009
Highly Cited
2009
Oxyma: an efficient additive for peptide synthesis to replace the benzotriazole-based HOBt and HOAt with a lower risk of explosion.
Oxyma [ethyl 2-cyano-2-(hydroxyimino)acetate] has been tested as an additive for use in the carbodiimide approach for formation… Expand
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Highly Cited
2009
Highly Cited
2009
COMU: a safer and more effective replacement for benzotriazole-based uronium coupling reagents.
We describe a new family of uronium-type coupling reagents that differ in their iminium moieties and leaving groups. The presence… Expand
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