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estradiol mustard

Known as: p-(N,N-bis(2-chloroethyl)amino)phenylacetic acid 17-beta-estradiol diester 
A conjugate of two agents, estradiol and an alkylating mustard (usually mechlorethamine or non-nitrogen mustard). Estramustine is one such agent (see… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

NSC 112259

Broader (1)

Nitrogen Mustard Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Effects of synthetic bis-β-chloroethylamine estrogen derivatives on proliferation of skin sarcoma cells
The effects of four new synthetic bis-β-chloroethylamine-containing estrogens and known cytostatic agents chlorophenacyl and… Expand
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Highly Cited
1985
Highly Cited
1985
Effect of estramustine phosphate on the assembly of isolated bovine brain microtubules and fast axonal transport in the frog sciatic nerve.
Estramustine phosphate (0.01 to 0.5 mM), an estradiol mustard derivative used in the therapy of prostatic carcinoma, inhibited… Expand
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Review
1983
Review
1983
Guide-lines in the design of new antiestrogens and cytotoxic-linked estrogens for the treatment of breast cancer.
Antiestrogens (Tamoxifen) are used for the treatment of breast cancer. However these compounds are also weak estrogens that may… Expand
1976
1976
Affinity of estradiol mustard for estrogen receptors and its enzymatic degradation in uterine and breast cancer cytosols
Estradiol mustard (EM) is the 3,17β‐diester of estradiol‐17β (E2) with the nitrogen mustard derivative chlorphenacyl. The ability… Expand
1975
1975
Effects of cancer chemotherapeutic agents on endocrine organs and serum levels of estrogens, progesterone, prolactin, and luteinizing hormone.
The effects of the following cancer chemotherapeutic agents on serum hormonal levels, estrous cycles, and endocrine organs were… Expand
1974
1974
Estrogen receptor interaction with the antitumor agent estradiol mustard.
1974
1974
Estradiol mustard (NSC-112259) and phenester (NSC-116785): possible mediation of action by estrogen binding protein.
The ability of estradiol mustard to bind receptors in rat uterine cytosol (as measured by the inhibition of binding of estradiol… Expand
1973
1973
Estradiol mustard (NSC-112259)--clinical brochure.
1972
1972
Alkylating analogs of peptide hormones. 2. Synthesis and properties of p-(N,N-bis(2-chloroethyl)amino)phenylbutyryl derivatives of angiotensin II.
1967
1967
Research on compounds with antiblastic activity. XXX. p-(N,N-bis-(beta-chloroethyl)amino)benzylidene derivatives of some cyclopentanones.
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