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estradiol-3-glucuronide

Known as: beta-D-Glucopyranosiduronic acid, (17 beta)-17-hydroxyestra-1,3,5(10)-trien-3-yl 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Estradiol
analogs & derivativesestradiol-17 beta-glucuronide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain
We have recently shown that several classes of glucuronide metabolites, including the morphine metabolite morphine-3-glucuronide… Expand
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2014
2014
Comparing the glucuronidation capacity of the feline liver with substrate-specific glucuronidation in dogs.
This study aimed to assess the overall glucuronidation capacity of cats, using prototypic substrates identified for human UDP… Expand
2011
2011
Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2)
Background Multidrug resistance-associated protein 2 (MRP2; ABCC2) mediates the biliary excretion of glutathione, glucuronide… Expand
Highly Cited
2008
Highly Cited
2008
Effect of the β‐glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP‐glucuronosyltransferases
Glucuronidation studies using microsomes and recombinant uridine diphosphoglucuronosyltransferases (UGTs) can be complicated by… Expand
2008
2008
In vivo chronic exposure to heroin or naltrexone selectively inhibits liver microsome formation of estradiol-3-glucuronide in the rat.
We have previously found that repeated exposure to heroin reduces liver synthesis of morphine-3-glucuronide (M3G) and increases… Expand
2004
2004
Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice.
Pain in sickle cell anemia (SCA) is clinically managed with opioid analgesics. There are reports that SCA patients tolerate high… Expand
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Highly Cited
2003
Highly Cited
2003
The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases.
Traditionally, the Michaelis-Menten equation has been used to determine kinetic parameters for in vitro glucuronidation assays… Expand
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2002
2002
Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics.
We have developed a sensitive and specific HPLC-fluorescence assay for the determination of estradiol-3-glucuronide and estradiol… Expand
Highly Cited
1978
Highly Cited
1978
Metabolism of androgens and estrogens by human fecal microorganisms.
Abstract Modifications of androgens and estrogens were observed in incubations with mixed human fecal cultures. Both oxidative… Expand
1977
1977
In vitro and in vivo studies on the metabolism of estrogens and their sulfates in guinea pigs.
Labelled estradiol-17 beta(E2) or estrone (E1), when incubated with guinea pig liver slices, is metabolized by two main pathways… Expand
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