establishment of granzyme B localization to T cell secretory granule

Known as: establishment of granzyme B localization in T-lymphocyte secretory granule, establishment of granzyme B localization in T lymphocyte secretory granule, establishment of granzyme B localization in T cell secretory granule 
The directed movement of the protease granzyme B to a location within a secretory granule in a T cell. [GOC:mah]
National Institutes of Health

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granzyme B localization to T cell secretory granule

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Review
2010
Review
2010
Granzyme A activates another way to die.
Granzyme A (GzmA) is the most abundant serine protease in killer cell cytotoxic granules. GzmA activates a novel programed cell… (More)
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Highly Cited
2008
Highly Cited
2008
Human and mouse granzyme A induce a proinflammatory cytokine response.
Granzyme A (GzmA) is considered a major proapoptotic protease. We have discovered that GzmA-induced cell death involves rapid… (More)
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2006
2006
The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.
Granzyme B, a serine protease derived from cytotoxic T lymphocyte (CTL) and Natural Killer (NK) cell granules, plays an important… (More)
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Highly Cited
2005
Highly Cited
2005
Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.
Granzyme B is a major cytotoxic T lymphocyte/natural killer (CTL/NK) granule protease that can activate members of the caspase… (More)
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Highly Cited
2005
Highly Cited
2005
Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage.
Cytotoxic T lymphocytes eliminate infected and tumor cells mainly by perforin/granzyme-induced apoptosis. Earlier studies… (More)
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Highly Cited
2003
Highly Cited
2003
Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.
Cell surface-bound heat shock protein 70 (Hsp70) renders tumor cells more sensitive to the cytolytic attack mediated by natural… (More)
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2001
2001
Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation.
Autoimmune processes are initiated when tolerance to self-proteins fails to be established or maintained and immune cells are… (More)
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Highly Cited
1999
Highly Cited
1999
Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status
Systemic autoimmune diseases are a genetically complex, heterogeneous group of disorders in which the immune system targets a… (More)
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Highly Cited
1996
Highly Cited
1996
New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis.
Lymphocyte granule-mediated apoptosis is postulated to entail the formation of membrane pores by perforin. Then soluble granzyme… (More)
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Highly Cited
1995
Highly Cited
1995
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
CYTOTOXIC T lymphocyte (CTL)-mediated cytotoxicity represents the body's major defence against virus-infected and tumorigenic… (More)
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