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epothilone 490

National Institutes of Health

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EpothilonesThiazoles

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Highly Cited
2002
Highly Cited
2002
Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.
A concise modular laboratory construction of the epothilone class of promising antitumor agents has been accomplished. For the… 
2002
2002
Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series.
A convergent ring-closing metathesis strategy has been employed for the highly concise syntheses of 10,11-dehydro-13,14-[17… 
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